Characterizing causality in cancer

Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emph...

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Detalles Bibliográficos
Autores principales: Rondeau, Elena, Larmonier, Nicolas, Pradeu, Thomas, Bikfalvi, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884405/
https://www.ncbi.nlm.nih.gov/pubmed/31782731
http://dx.doi.org/10.7554/eLife.53755
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author Rondeau, Elena
Larmonier, Nicolas
Pradeu, Thomas
Bikfalvi, Andreas
author_facet Rondeau, Elena
Larmonier, Nicolas
Pradeu, Thomas
Bikfalvi, Andreas
author_sort Rondeau, Elena
collection PubMed
description Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.
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spelling pubmed-68844052019-12-03 Characterizing causality in cancer Rondeau, Elena Larmonier, Nicolas Pradeu, Thomas Bikfalvi, Andreas eLife Cancer Biology Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors. eLife Sciences Publications, Ltd 2019-11-29 /pmc/articles/PMC6884405/ /pubmed/31782731 http://dx.doi.org/10.7554/eLife.53755 Text en © 2019, Rondeau et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cancer Biology
Rondeau, Elena
Larmonier, Nicolas
Pradeu, Thomas
Bikfalvi, Andreas
Characterizing causality in cancer
title Characterizing causality in cancer
title_full Characterizing causality in cancer
title_fullStr Characterizing causality in cancer
title_full_unstemmed Characterizing causality in cancer
title_short Characterizing causality in cancer
title_sort characterizing causality in cancer
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884405/
https://www.ncbi.nlm.nih.gov/pubmed/31782731
http://dx.doi.org/10.7554/eLife.53755
work_keys_str_mv AT rondeauelena characterizingcausalityincancer
AT larmoniernicolas characterizingcausalityincancer
AT pradeuthomas characterizingcausalityincancer
AT bikfalviandreas characterizingcausalityincancer

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