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Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
Acute Myeloid Leukemia (AML) develops due to the acquisition of mutations from multiple functional classes. Here, we demonstrate that activating mutations in the granulocyte colony stimulating factor receptor (CSF3R), cooperate with loss of function mutations in the transcription factor CEBPA to pro...
Autores principales: | Braun, Theodore P., Okhovat, Mariam, Coblentz, Cody, Carratt, Sarah A., Foley, Amy, Schonrock, Zachary, Curtiss, Brittany M., Nevonen, Kimberly, Davis, Brett, Garcia, Brianna, LaTocha, Dorian, Weeder, Benjamin R., Grzadkowski, Michal R., Estabrook, Joey C., Manning, Hannah G., Watanabe-Smith, Kevin, Jeng, Sophia, Smith, Jenny L., Leonti, Amanda R., Ries, Rhonda E., McWeeney, Shannon, Di Genua, Cristina, Drissen, Roy, Nerlov, Claus, Meshinchi, Soheil, Carbone, Lucia, Druker, Brian J., Maxson, Julia E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884457/ https://www.ncbi.nlm.nih.gov/pubmed/31784538 http://dx.doi.org/10.1038/s41467-019-13364-2 |
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