Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides

Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) is involved in both intracellular membraneless organelles and extracellular tissues. Despite growing understanding of LLPS, molecular-level mechanisms behind this process are still not fully established. Here, we use h...

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Detalles Bibliográficos
Autores principales: Gabryelczyk, Bartosz, Cai, Hao, Shi, Xiangyan, Sun, Yue, Swinkels, Piet J. M., Salentinig, Stefan, Pervushin, Konstantin, Miserez, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884462/
https://www.ncbi.nlm.nih.gov/pubmed/31784535
http://dx.doi.org/10.1038/s41467-019-13469-8

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