Genomic and immune profiling of pre-invasive lung adenocarcinoma

Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenoc...

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Detalles Bibliográficos
Autores principales: Chen, Haiquan, Carrot-Zhang, Jian, Zhao, Yue, Hu, Haichuan, Freeman, Samuel S., Yu, Su, Ha, Gavin, Taylor, Alison M., Berger, Ashton C., Westlake, Lindsay, Zheng, Yuanting, Zhang, Jiyang, Ramachandran, Aruna, Zheng, Qiang, Pan, Yunjian, Zheng, Difan, Zheng, Shanbo, Cheng, Chao, Kuang, Muyu, Zhou, Xiaoyan, Zhang, Yang, Li, Hang, Ye, Ting, Ma, Yuan, Gao, Zhendong, Tao, Xiaoting, Han, Han, Shang, Jun, Yu, Ying, Bao, Ding, Huang, Yechao, Li, Xiangnan, Zhang, Yawei, Xiang, Jiaqing, Sun, Yihua, Li, Yuan, Cherniack, Andrew D., Campbell, Joshua D., Shi, Leming, Meyerson, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884501/
https://www.ncbi.nlm.nih.gov/pubmed/31784532
http://dx.doi.org/10.1038/s41467-019-13460-3
Descripción
Sumario:Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenocarcinomas. We have identified EGFR, RBM10, BRAF, ERBB2, TP53, KRAS, MAP2K1 and MET as significantly mutated genes in the pre/minimally invasive group. Classes of genome alterations that increase in frequency during the progression to malignancy are revealed. These include mutations in TP53, arm-level copy number alterations, and HLA loss of heterozygosity. Immune infiltration is correlated with copy number alterations of chromosome arm 6p, suggesting a link between arm-level events and the tumor immune environment.

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