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Genomic and immune profiling of pre-invasive lung adenocarcinoma
Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenoc...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884501/ https://www.ncbi.nlm.nih.gov/pubmed/31784532 http://dx.doi.org/10.1038/s41467-019-13460-3 |
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| author | Chen, Haiquan Carrot-Zhang, Jian Zhao, Yue Hu, Haichuan Freeman, Samuel S. Yu, Su Ha, Gavin Taylor, Alison M. Berger, Ashton C. Westlake, Lindsay Zheng, Yuanting Zhang, Jiyang Ramachandran, Aruna Zheng, Qiang Pan, Yunjian Zheng, Difan Zheng, Shanbo Cheng, Chao Kuang, Muyu Zhou, Xiaoyan Zhang, Yang Li, Hang Ye, Ting Ma, Yuan Gao, Zhendong Tao, Xiaoting Han, Han Shang, Jun Yu, Ying Bao, Ding Huang, Yechao Li, Xiangnan Zhang, Yawei Xiang, Jiaqing Sun, Yihua Li, Yuan Cherniack, Andrew D. Campbell, Joshua D. Shi, Leming Meyerson, Matthew |
| author_facet | Chen, Haiquan Carrot-Zhang, Jian Zhao, Yue Hu, Haichuan Freeman, Samuel S. Yu, Su Ha, Gavin Taylor, Alison M. Berger, Ashton C. Westlake, Lindsay Zheng, Yuanting Zhang, Jiyang Ramachandran, Aruna Zheng, Qiang Pan, Yunjian Zheng, Difan Zheng, Shanbo Cheng, Chao Kuang, Muyu Zhou, Xiaoyan Zhang, Yang Li, Hang Ye, Ting Ma, Yuan Gao, Zhendong Tao, Xiaoting Han, Han Shang, Jun Yu, Ying Bao, Ding Huang, Yechao Li, Xiangnan Zhang, Yawei Xiang, Jiaqing Sun, Yihua Li, Yuan Cherniack, Andrew D. Campbell, Joshua D. Shi, Leming Meyerson, Matthew |
| author_sort | Chen, Haiquan |
| collection | PubMed |
| description | Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenocarcinomas. We have identified EGFR, RBM10, BRAF, ERBB2, TP53, KRAS, MAP2K1 and MET as significantly mutated genes in the pre/minimally invasive group. Classes of genome alterations that increase in frequency during the progression to malignancy are revealed. These include mutations in TP53, arm-level copy number alterations, and HLA loss of heterozygosity. Immune infiltration is correlated with copy number alterations of chromosome arm 6p, suggesting a link between arm-level events and the tumor immune environment. |
| format | Online Article Text |
| id | pubmed-6884501 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68845012019-12-03 Genomic and immune profiling of pre-invasive lung adenocarcinoma Chen, Haiquan Carrot-Zhang, Jian Zhao, Yue Hu, Haichuan Freeman, Samuel S. Yu, Su Ha, Gavin Taylor, Alison M. Berger, Ashton C. Westlake, Lindsay Zheng, Yuanting Zhang, Jiyang Ramachandran, Aruna Zheng, Qiang Pan, Yunjian Zheng, Difan Zheng, Shanbo Cheng, Chao Kuang, Muyu Zhou, Xiaoyan Zhang, Yang Li, Hang Ye, Ting Ma, Yuan Gao, Zhendong Tao, Xiaoting Han, Han Shang, Jun Yu, Ying Bao, Ding Huang, Yechao Li, Xiangnan Zhang, Yawei Xiang, Jiaqing Sun, Yihua Li, Yuan Cherniack, Andrew D. Campbell, Joshua D. Shi, Leming Meyerson, Matthew Nat Commun Article Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenocarcinomas. We have identified EGFR, RBM10, BRAF, ERBB2, TP53, KRAS, MAP2K1 and MET as significantly mutated genes in the pre/minimally invasive group. Classes of genome alterations that increase in frequency during the progression to malignancy are revealed. These include mutations in TP53, arm-level copy number alterations, and HLA loss of heterozygosity. Immune infiltration is correlated with copy number alterations of chromosome arm 6p, suggesting a link between arm-level events and the tumor immune environment. Nature Publishing Group UK 2019-11-29 /pmc/articles/PMC6884501/ /pubmed/31784532 http://dx.doi.org/10.1038/s41467-019-13460-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Chen, Haiquan Carrot-Zhang, Jian Zhao, Yue Hu, Haichuan Freeman, Samuel S. Yu, Su Ha, Gavin Taylor, Alison M. Berger, Ashton C. Westlake, Lindsay Zheng, Yuanting Zhang, Jiyang Ramachandran, Aruna Zheng, Qiang Pan, Yunjian Zheng, Difan Zheng, Shanbo Cheng, Chao Kuang, Muyu Zhou, Xiaoyan Zhang, Yang Li, Hang Ye, Ting Ma, Yuan Gao, Zhendong Tao, Xiaoting Han, Han Shang, Jun Yu, Ying Bao, Ding Huang, Yechao Li, Xiangnan Zhang, Yawei Xiang, Jiaqing Sun, Yihua Li, Yuan Cherniack, Andrew D. Campbell, Joshua D. Shi, Leming Meyerson, Matthew Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title | Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_full | Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_fullStr | Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_full_unstemmed | Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_short | Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_sort | genomic and immune profiling of pre-invasive lung adenocarcinoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884501/ https://www.ncbi.nlm.nih.gov/pubmed/31784532 http://dx.doi.org/10.1038/s41467-019-13460-3 |
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