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Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets

Routine use of antibiotics in livestock animals strongly contributed to the creation of multidrug-resistant Salmonella Typhimurium strains (STM). Vaccination is an alternative to the use of antibiotics but often suffers from low efficacy. The present study investigated whether long-chain inulin (lcI...

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Autores principales: Lépine, Alexia F. P., Konstanti, Prokopis, Borewicz, Klaudyna, Resink, Jan-Willem, de Wit, Nicole J., Vos, Paul de, Smidt, Hauke, Mes, Jurriaan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884548/
https://www.ncbi.nlm.nih.gov/pubmed/31784576
http://dx.doi.org/10.1038/s41598-019-54353-1
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author Lépine, Alexia F. P.
Konstanti, Prokopis
Borewicz, Klaudyna
Resink, Jan-Willem
de Wit, Nicole J.
Vos, Paul de
Smidt, Hauke
Mes, Jurriaan J.
author_facet Lépine, Alexia F. P.
Konstanti, Prokopis
Borewicz, Klaudyna
Resink, Jan-Willem
de Wit, Nicole J.
Vos, Paul de
Smidt, Hauke
Mes, Jurriaan J.
author_sort Lépine, Alexia F. P.
collection PubMed
description Routine use of antibiotics in livestock animals strongly contributed to the creation of multidrug-resistant Salmonella Typhimurium strains (STM). Vaccination is an alternative to the use of antibiotics but often suffers from low efficacy. The present study investigated whether long-chain inulin (lcITF) and Lactobacillus acidophilus W37 (LaW37) can support vaccination efficacy against STM and if the interventions influence possible gut microbiota changes. Piglets received daily supplementation until sacrifice. Animals were vaccinated on day 25 after birth, one day after weaning, and were challenged with STM on days 52–54. Dietary intervention with lcITF/LaW37 enhanced vaccination efficacy by 2-fold during challenge and resulted in higher relative abundance of Prevotellaceae and lower relative abundance of Lactobacillaceae in faeces. Although strongest microbial effects were observed post STM challenge on day 55, transient effects of the lcITF/LaW37 intervention were also detected on day 10 after birth, and post-weaning on day 30 where increased relative abundance of faecal lactobacilli was correlated with higher faecal consistency. LcITF treatment increased post-weaning feed efficiency and faecal consistency but did not support vaccination efficacy. Vaccination in immune-immature young animals can be enhanced with functional additives which can simultaneously promote health in an ingredient-dependent fashion.
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spelling pubmed-68845482019-12-06 Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets Lépine, Alexia F. P. Konstanti, Prokopis Borewicz, Klaudyna Resink, Jan-Willem de Wit, Nicole J. Vos, Paul de Smidt, Hauke Mes, Jurriaan J. Sci Rep Article Routine use of antibiotics in livestock animals strongly contributed to the creation of multidrug-resistant Salmonella Typhimurium strains (STM). Vaccination is an alternative to the use of antibiotics but often suffers from low efficacy. The present study investigated whether long-chain inulin (lcITF) and Lactobacillus acidophilus W37 (LaW37) can support vaccination efficacy against STM and if the interventions influence possible gut microbiota changes. Piglets received daily supplementation until sacrifice. Animals were vaccinated on day 25 after birth, one day after weaning, and were challenged with STM on days 52–54. Dietary intervention with lcITF/LaW37 enhanced vaccination efficacy by 2-fold during challenge and resulted in higher relative abundance of Prevotellaceae and lower relative abundance of Lactobacillaceae in faeces. Although strongest microbial effects were observed post STM challenge on day 55, transient effects of the lcITF/LaW37 intervention were also detected on day 10 after birth, and post-weaning on day 30 where increased relative abundance of faecal lactobacilli was correlated with higher faecal consistency. LcITF treatment increased post-weaning feed efficiency and faecal consistency but did not support vaccination efficacy. Vaccination in immune-immature young animals can be enhanced with functional additives which can simultaneously promote health in an ingredient-dependent fashion. Nature Publishing Group UK 2019-11-29 /pmc/articles/PMC6884548/ /pubmed/31784576 http://dx.doi.org/10.1038/s41598-019-54353-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lépine, Alexia F. P.
Konstanti, Prokopis
Borewicz, Klaudyna
Resink, Jan-Willem
de Wit, Nicole J.
Vos, Paul de
Smidt, Hauke
Mes, Jurriaan J.
Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets
title Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets
title_full Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets
title_fullStr Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets
title_full_unstemmed Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets
title_short Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets
title_sort combined dietary supplementation of long chain inulin and lactobacillus acidophilus w37 supports oral vaccination efficacy against salmonella typhimurium in piglets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884548/
https://www.ncbi.nlm.nih.gov/pubmed/31784576
http://dx.doi.org/10.1038/s41598-019-54353-1
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