Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD

Expanded GGGGCC (G(4)C(2)) repeats in C9ORF72 cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How RNAs containing expanded G(4)C(2) repeats are transcribed in human neurons is largely unknown. Here we describe a Drosophila model in which poly(GR) expression in adult neur...

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Detalles Bibliográficos
Autores principales: Yuva-Aydemir, Yeliz, Almeida, Sandra, Krishnan, Gopinath, Gendron, Tania F., Gao, Fen-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884579/
https://www.ncbi.nlm.nih.gov/pubmed/31784536
http://dx.doi.org/10.1038/s41467-019-13477-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884579/
https://www.ncbi.nlm.nih.gov/pubmed/31784536
http://dx.doi.org/10.1038/s41467-019-13477-8

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