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Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease

An increase of heart rate to physical or mental stress reflects the ability of the autonomous nervous system and the heart to respond adequately. Hyperventilation is a user-controlled breathing maneuver that has a significant impact on coronary function and hemodynamics. Thus, we aimed to investigat...

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Autores principales: Hawkins, Selwynne M., Guensch, Dominik P., Friedrich, Matthias G., Vinco, Giulia, Nadeshalingham, Gobinath, White, Michel, Mongeon, Francois-Pierre, Hillier, Elizabeth, Teixeira, Tiago, Flewitt, Jacqueline A., Eberle, Balthasar, Fischer, Kady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884614/
https://www.ncbi.nlm.nih.gov/pubmed/31784617
http://dx.doi.org/10.1038/s41598-019-54375-9
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author Hawkins, Selwynne M.
Guensch, Dominik P.
Friedrich, Matthias G.
Vinco, Giulia
Nadeshalingham, Gobinath
White, Michel
Mongeon, Francois-Pierre
Hillier, Elizabeth
Teixeira, Tiago
Flewitt, Jacqueline A.
Eberle, Balthasar
Fischer, Kady
author_facet Hawkins, Selwynne M.
Guensch, Dominik P.
Friedrich, Matthias G.
Vinco, Giulia
Nadeshalingham, Gobinath
White, Michel
Mongeon, Francois-Pierre
Hillier, Elizabeth
Teixeira, Tiago
Flewitt, Jacqueline A.
Eberle, Balthasar
Fischer, Kady
author_sort Hawkins, Selwynne M.
collection PubMed
description An increase of heart rate to physical or mental stress reflects the ability of the autonomous nervous system and the heart to respond adequately. Hyperventilation is a user-controlled breathing maneuver that has a significant impact on coronary function and hemodynamics. Thus, we aimed to investigate if the heart rate response to hyperventilation (HRR(HV)) can provide clinically useful information. A pooled analysis of the HRR(HV) after 60 s of hyperventilation was conducted in 282 participants including healthy controls; patients with heart failure (HF); coronary artery disease (CAD); a combination of both; or patients suspected of CAD but with a normal angiogram. Hyperventilation significantly increased heart rate in all groups, although healthy controls aged 55 years and older (15 ± 9 bpm) had a larger HRR(HV) than each of the disease groups (HF: 6 ± 6, CAD: 8 ± 8, CAD+/HF+: 6 ± 4, and CAD−/HF−: 8 ± 6 bpm, p < 0.001). No significant differences were found between disease groups. The HRR(HV) may serve as an easily measurable additional marker of cardiovascular health. Future studies should test its diagnostic potential as a simple, inexpensive pre-screening test to improve patient selection for other diagnostic exams.
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spelling pubmed-68846142019-12-06 Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease Hawkins, Selwynne M. Guensch, Dominik P. Friedrich, Matthias G. Vinco, Giulia Nadeshalingham, Gobinath White, Michel Mongeon, Francois-Pierre Hillier, Elizabeth Teixeira, Tiago Flewitt, Jacqueline A. Eberle, Balthasar Fischer, Kady Sci Rep Article An increase of heart rate to physical or mental stress reflects the ability of the autonomous nervous system and the heart to respond adequately. Hyperventilation is a user-controlled breathing maneuver that has a significant impact on coronary function and hemodynamics. Thus, we aimed to investigate if the heart rate response to hyperventilation (HRR(HV)) can provide clinically useful information. A pooled analysis of the HRR(HV) after 60 s of hyperventilation was conducted in 282 participants including healthy controls; patients with heart failure (HF); coronary artery disease (CAD); a combination of both; or patients suspected of CAD but with a normal angiogram. Hyperventilation significantly increased heart rate in all groups, although healthy controls aged 55 years and older (15 ± 9 bpm) had a larger HRR(HV) than each of the disease groups (HF: 6 ± 6, CAD: 8 ± 8, CAD+/HF+: 6 ± 4, and CAD−/HF−: 8 ± 6 bpm, p < 0.001). No significant differences were found between disease groups. The HRR(HV) may serve as an easily measurable additional marker of cardiovascular health. Future studies should test its diagnostic potential as a simple, inexpensive pre-screening test to improve patient selection for other diagnostic exams. Nature Publishing Group UK 2019-11-29 /pmc/articles/PMC6884614/ /pubmed/31784617 http://dx.doi.org/10.1038/s41598-019-54375-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hawkins, Selwynne M.
Guensch, Dominik P.
Friedrich, Matthias G.
Vinco, Giulia
Nadeshalingham, Gobinath
White, Michel
Mongeon, Francois-Pierre
Hillier, Elizabeth
Teixeira, Tiago
Flewitt, Jacqueline A.
Eberle, Balthasar
Fischer, Kady
Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease
title Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease
title_full Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease
title_fullStr Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease
title_full_unstemmed Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease
title_short Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease
title_sort hyperventilation-induced heart rate response as a potential marker for cardiovascular disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884614/
https://www.ncbi.nlm.nih.gov/pubmed/31784617
http://dx.doi.org/10.1038/s41598-019-54375-9
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