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Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures

Antarctic fish belonging to Notothenioidei represent an extraordinary example of radiation in the cold. In addition to the absence of hemoglobin, icefish show a number of other striking peculiarities including large-diameter blood vessels, high vascular densities, mitochondria-rich muscle cells, and...

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Autores principales: Bargelloni, Luca, Babbucci, Massimiliano, Ferraresso, Serena, Papetti, Chiara, Vitulo, Nicola, Carraro, Roberta, Pauletto, Marianna, Santovito, Gianfranco, Lucassen, Magnus, Mark, Felix Christopher, Zane, Lorenzo, Patarnello, Tomaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884616/
https://www.ncbi.nlm.nih.gov/pubmed/31815198
http://dx.doi.org/10.1038/s42003-019-0685-y
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author Bargelloni, Luca
Babbucci, Massimiliano
Ferraresso, Serena
Papetti, Chiara
Vitulo, Nicola
Carraro, Roberta
Pauletto, Marianna
Santovito, Gianfranco
Lucassen, Magnus
Mark, Felix Christopher
Zane, Lorenzo
Patarnello, Tomaso
author_facet Bargelloni, Luca
Babbucci, Massimiliano
Ferraresso, Serena
Papetti, Chiara
Vitulo, Nicola
Carraro, Roberta
Pauletto, Marianna
Santovito, Gianfranco
Lucassen, Magnus
Mark, Felix Christopher
Zane, Lorenzo
Patarnello, Tomaso
author_sort Bargelloni, Luca
collection PubMed
description Antarctic fish belonging to Notothenioidei represent an extraordinary example of radiation in the cold. In addition to the absence of hemoglobin, icefish show a number of other striking peculiarities including large-diameter blood vessels, high vascular densities, mitochondria-rich muscle cells, and unusual mitochondrial architecture. In order to investigate the bases of icefish adaptation to the extreme Southern Ocean conditions we sequenced the complete genome of the icefish Chionodraco myersi. Comparative analyses of the icefish genome with those of other teleost species, including two additional white-blooded and five red-blooded notothenioids, provided a new perspective on the evolutionary loss of globin genes. Muscle transcriptome comparative analyses against red-blooded notothenioids as well as temperate fish revealed the peculiar regulation of genes involved in mitochondrial function in icefish. Gene duplication and promoter sequence divergence were identified as genome-wide patterns that likely contributed to the broad transcriptional program underlying the unique features of icefish mitochondria.
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spelling pubmed-68846162019-12-06 Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures Bargelloni, Luca Babbucci, Massimiliano Ferraresso, Serena Papetti, Chiara Vitulo, Nicola Carraro, Roberta Pauletto, Marianna Santovito, Gianfranco Lucassen, Magnus Mark, Felix Christopher Zane, Lorenzo Patarnello, Tomaso Commun Biol Article Antarctic fish belonging to Notothenioidei represent an extraordinary example of radiation in the cold. In addition to the absence of hemoglobin, icefish show a number of other striking peculiarities including large-diameter blood vessels, high vascular densities, mitochondria-rich muscle cells, and unusual mitochondrial architecture. In order to investigate the bases of icefish adaptation to the extreme Southern Ocean conditions we sequenced the complete genome of the icefish Chionodraco myersi. Comparative analyses of the icefish genome with those of other teleost species, including two additional white-blooded and five red-blooded notothenioids, provided a new perspective on the evolutionary loss of globin genes. Muscle transcriptome comparative analyses against red-blooded notothenioids as well as temperate fish revealed the peculiar regulation of genes involved in mitochondrial function in icefish. Gene duplication and promoter sequence divergence were identified as genome-wide patterns that likely contributed to the broad transcriptional program underlying the unique features of icefish mitochondria. Nature Publishing Group UK 2019-11-29 /pmc/articles/PMC6884616/ /pubmed/31815198 http://dx.doi.org/10.1038/s42003-019-0685-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Bargelloni, Luca
Babbucci, Massimiliano
Ferraresso, Serena
Papetti, Chiara
Vitulo, Nicola
Carraro, Roberta
Pauletto, Marianna
Santovito, Gianfranco
Lucassen, Magnus
Mark, Felix Christopher
Zane, Lorenzo
Patarnello, Tomaso
Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures
title Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures
title_full Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures
title_fullStr Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures
title_full_unstemmed Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures
title_short Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures
title_sort draft genome assembly and transcriptome data of the icefish chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884616/
https://www.ncbi.nlm.nih.gov/pubmed/31815198
http://dx.doi.org/10.1038/s42003-019-0685-y
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