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Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures
Antarctic fish belonging to Notothenioidei represent an extraordinary example of radiation in the cold. In addition to the absence of hemoglobin, icefish show a number of other striking peculiarities including large-diameter blood vessels, high vascular densities, mitochondria-rich muscle cells, and...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884616/ https://www.ncbi.nlm.nih.gov/pubmed/31815198 http://dx.doi.org/10.1038/s42003-019-0685-y |
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author | Bargelloni, Luca Babbucci, Massimiliano Ferraresso, Serena Papetti, Chiara Vitulo, Nicola Carraro, Roberta Pauletto, Marianna Santovito, Gianfranco Lucassen, Magnus Mark, Felix Christopher Zane, Lorenzo Patarnello, Tomaso |
author_facet | Bargelloni, Luca Babbucci, Massimiliano Ferraresso, Serena Papetti, Chiara Vitulo, Nicola Carraro, Roberta Pauletto, Marianna Santovito, Gianfranco Lucassen, Magnus Mark, Felix Christopher Zane, Lorenzo Patarnello, Tomaso |
author_sort | Bargelloni, Luca |
collection | PubMed |
description | Antarctic fish belonging to Notothenioidei represent an extraordinary example of radiation in the cold. In addition to the absence of hemoglobin, icefish show a number of other striking peculiarities including large-diameter blood vessels, high vascular densities, mitochondria-rich muscle cells, and unusual mitochondrial architecture. In order to investigate the bases of icefish adaptation to the extreme Southern Ocean conditions we sequenced the complete genome of the icefish Chionodraco myersi. Comparative analyses of the icefish genome with those of other teleost species, including two additional white-blooded and five red-blooded notothenioids, provided a new perspective on the evolutionary loss of globin genes. Muscle transcriptome comparative analyses against red-blooded notothenioids as well as temperate fish revealed the peculiar regulation of genes involved in mitochondrial function in icefish. Gene duplication and promoter sequence divergence were identified as genome-wide patterns that likely contributed to the broad transcriptional program underlying the unique features of icefish mitochondria. |
format | Online Article Text |
id | pubmed-6884616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68846162019-12-06 Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures Bargelloni, Luca Babbucci, Massimiliano Ferraresso, Serena Papetti, Chiara Vitulo, Nicola Carraro, Roberta Pauletto, Marianna Santovito, Gianfranco Lucassen, Magnus Mark, Felix Christopher Zane, Lorenzo Patarnello, Tomaso Commun Biol Article Antarctic fish belonging to Notothenioidei represent an extraordinary example of radiation in the cold. In addition to the absence of hemoglobin, icefish show a number of other striking peculiarities including large-diameter blood vessels, high vascular densities, mitochondria-rich muscle cells, and unusual mitochondrial architecture. In order to investigate the bases of icefish adaptation to the extreme Southern Ocean conditions we sequenced the complete genome of the icefish Chionodraco myersi. Comparative analyses of the icefish genome with those of other teleost species, including two additional white-blooded and five red-blooded notothenioids, provided a new perspective on the evolutionary loss of globin genes. Muscle transcriptome comparative analyses against red-blooded notothenioids as well as temperate fish revealed the peculiar regulation of genes involved in mitochondrial function in icefish. Gene duplication and promoter sequence divergence were identified as genome-wide patterns that likely contributed to the broad transcriptional program underlying the unique features of icefish mitochondria. Nature Publishing Group UK 2019-11-29 /pmc/articles/PMC6884616/ /pubmed/31815198 http://dx.doi.org/10.1038/s42003-019-0685-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bargelloni, Luca Babbucci, Massimiliano Ferraresso, Serena Papetti, Chiara Vitulo, Nicola Carraro, Roberta Pauletto, Marianna Santovito, Gianfranco Lucassen, Magnus Mark, Felix Christopher Zane, Lorenzo Patarnello, Tomaso Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures |
title | Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures |
title_full | Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures |
title_fullStr | Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures |
title_full_unstemmed | Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures |
title_short | Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures |
title_sort | draft genome assembly and transcriptome data of the icefish chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884616/ https://www.ncbi.nlm.nih.gov/pubmed/31815198 http://dx.doi.org/10.1038/s42003-019-0685-y |
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