Cargando…

Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone

Increased legal availability of cannabis has led to a common misconception that it is a safe natural remedy for, amongst others, pregnancy-related ailments like morning sickness. Emerging clinical evidence, however, indicates that prenatal cannabis exposure (PCE) predisposes offspring to various neu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frau, Roberto, Miczán, Vivien, Traccis, Francesco, Aroni, Sonia, Pongor, Csaba I., Saba, Pierluigi, Serra, Valeria, Sagheddu, Claudia, Fanni, Silvia, Congiu, Mauro, Devoto, Paola, Cheer, Joseph F., Katona, István, Melis, Miriam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884689/ https://www.ncbi.nlm.nih.gov/pubmed/31611707 http://dx.doi.org/10.1038/s41593-019-0512-2

Ejemplares similares

Prenatal THC Does Not Affect Female Mesolimbic Dopaminergic System in Preadolescent Rats
por: Traccis, Francesco, et al.
Publicado: (2021)

Combined α(2)- and D(2)-receptor blockade activates noradrenergic and dopaminergic neurons, but extracellular dopamine in the prefrontal cortex is determined by uptake and release from noradrenergic terminals
por: Sagheddu, Claudia, et al.
Publicado: (2023)

The PPARα agonist fenofibrate attenuates disruption of dopamine function in a maternal immune activation rat model of schizophrenia
por: De Felice, Marta, et al.
Publicado: (2018)

Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice
por: Wong, Peiyan, et al.
Publicado: (2012)

Gender Differences in the Outcome of Offspring Prenatally Exposed to Drugs of Abuse
por: Traccis, Francesco, et al.
Publicado: (2020)

Increased elasticity of sucrose demand during hyperdopaminergic states in rats
por: Minnaard, A. Maryse, et al.
Publicado: (2022)

Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter
por: Traktirov, Dmitrii S., et al.
Publicado: (2023)

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states
por: Verharen, Jeroen P. H., et al.
Publicado: (2018)

Proceedings: Pregnenolone metabolism in patients with carcinoma.
por: O'Higgins, N., et al.
Publicado: (1974)

Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting
por: Barbiero, Isabella, et al.
Publicado: (2021)

NECAB1 and NECAB2 are Prevalent Calcium-Binding Proteins of CB(1)/CCK-Positive GABAergic Interneurons
por: Miczán, Vivien, et al.
Publicado: (2020)

S232. ALPHA7 NICOTINIC RECEPTOR AGONISTS REVERSE THE HYPERDOPAMINERGIC STATE IN THE MAM MODEL OF SCHIZOPHRENIA
por: Neves, Gilda, et al.
Publicado: (2018)

Noradrenergic Source of Dopamine Assessed by Microdialysis in the Medial Prefrontal Cortex
por: Devoto, Paola, et al.
Publicado: (2020)

TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
por: Lejri, Imane, et al.
Publicado: (2019)

Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers
por: Bracci, Massimo, et al.
Publicado: (2023)

Selective inhibition of dopamine‐beta‐hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex
por: Devoto, Paola, et al.
Publicado: (2015)

ABHD4-dependent developmental anoikis safeguards the embryonic brain
por: László, Zsófia I., et al.
Publicado: (2020)

Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density
Publicado: (1993)

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone
por: Majeed, Yasser, et al.
Publicado: (2012)

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand
por: Harteneck, Christian
Publicado: (2013)

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis
por: Witzig, Melissa, et al.
Publicado: (2020)

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
por: Ramírez, Sara, et al.
Publicado: (2022)

Pallidal Hyperdopaminergic Innervation Underlying D2 Receptor-Dependent Behavioral Deficits in the Schizophrenia Animal Model Established by EGF
por: Sotoyama, Hidekazu, et al.
Publicado: (2011)

Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice
por: Busquets-Garcia, Arnau, et al.
Publicado: (2017)

Deficient pregnenolone synthesis associated with congenital adrenal hyperplasia and organelle dysfunction
por: Bose, Himangshu S, et al.
Publicado: (2019)

Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase
por: Loke, Steffen, et al.
Publicado: (2021)

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells
por: Roy, Sougata, et al.
Publicado: (2021)

A synthetic pregnenolone analog promotes microtubule dynamics and neural development
por: Kolas, Viktoryia, et al.
Publicado: (2022)

Delta-8-THC: Delta-9-THC’s nicer younger sibling?
por: Kruger, Jessica S., et al.
Publicado: (2022)

Sperm capacitation and transcripts levels are altered by in vitro THC exposure
por: Truong, Vivien B., et al.
Publicado: (2023)

Development and validation of an automated liquid-liquid extraction GC/MS method for the determination of THC, 11-OH-THC, and free THC-carboxylic acid (THC-COOH) from blood serum
por: Purschke, Kirsten, et al.
Publicado: (2016)

Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling
por: Cuccurazzu, Bruna, et al.
Publicado: (2018)

Antitumor effects of THC.
por: Huff, J, et al.
Publicado: (2000)

Traditionally hyperdopaminergic state in the basal forebrain has been described as the major pathophysiological basis while subsequent research focussed on the serotonergic system.
Publicado: (2022)

Rapid In Situ Detection of THC and CBD in Cannabis sativa L. by 1064 nm Raman Spectroscopy
por: Porcu, Stefania, et al.
Publicado: (2022)

Pregnenolone Sulfate Potentiates the Inwardly Rectifying K(+) Channel Kir2.3
por: Kobayashi, Toru, et al.
Publicado: (2009)

SUN-219 Electron Transport Chain Complex 2 in Mitochondrial Pregnenolone Synthesis
por: Bose, Himangshu S, et al.
Publicado: (2020)

Glucocorticoids, Stress and Delta-9 Tetrahydrocannabinol (THC) during Early Embryonic Development
por: Kuzma-Hunt, Alexander G., et al.
Publicado: (2021)

Can Hemp Help? Low-THC Cannabis and Non-THC Cannabinoids for the Treatment of Cancer
por: Afrin, Farjana, et al.
Publicado: (2020)

The safety of lookalikes: a new THC beverage enhancer and a non-THC counterpart
por: Brown, Geoffrey W., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6mj9qh93q28nr4asshn1ks37j1