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The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening
BACKGROUND: To evaluate the meaning of serum CRP, ESR, and D-Dimer in the diagnosis of prosthetic joint infection. METHODS: In a retrospective study, 101 patients presented with osteoarthritis, PJI, and aseptic loosening were divided into three groups according to the type of operation they received...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884846/ https://www.ncbi.nlm.nih.gov/pubmed/31783874 http://dx.doi.org/10.1186/s13018-019-1461-x |
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author | Huang, Jincheng Zhang, Yongchao Wang, Zhen Dong, Yonghui Zhao, Yongqiang Zheng, Jia Lian, Hongkai Jin, Yi |
author_facet | Huang, Jincheng Zhang, Yongchao Wang, Zhen Dong, Yonghui Zhao, Yongqiang Zheng, Jia Lian, Hongkai Jin, Yi |
author_sort | Huang, Jincheng |
collection | PubMed |
description | BACKGROUND: To evaluate the meaning of serum CRP, ESR, and D-Dimer in the diagnosis of prosthetic joint infection. METHODS: In a retrospective study, 101 patients presented with osteoarthritis, PJI, and aseptic loosening were divided into three groups according to the type of operation they received in our department from June 2016 to December 2018: group A, 44 patients treated with primary arthroplasty; group B, 31 PJI patients treated with resection arthroplasty and spacer insertion surgery; group C, 26 aseptic loosening patients treated with revision arthroplasty. Data such as gender, age, preoperative serum CRP, ESR, and D-Dimer level were compared among the three different groups. RESULTS: There are no statistically significant differences when comparing general data such as gender and age in patients from the three different groups. However, Serum CRP level in group B (43.49 ± 10.00 mg/L) is significantly higher than in group A (2.97 ± 0.75 mg/L) and C (4.80 ± 1.26 mg/L). Serum ESR level in group B (49.84 ± 5.48 μg/L) is significantly higher than those in group A (15.28 ± 2.63 μg/L) and C (22.50 ± 3.47 μg/L). Serum D-Dimer level in group B (1.58 ± 0.17 μg/L) is significantly higher than that in group A (0.51 ± 0.50 μg/L), but similar with group C (1.22 ± 0.29 μg/L). There are no statistically significant differences when compared with sensitivity and specificity of CRP, ESR, and D-Dimer in the diagnosis of PJI among patients from the three different groups when D-Dimer > 0.85 μg/L was set as the optimal threshold value for the diagnosis of PJI. CONCLUSION: D-Dimer is not a parameter to distinguish between aseptic loosening and PJI. |
format | Online Article Text |
id | pubmed-6884846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68848462019-12-03 The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening Huang, Jincheng Zhang, Yongchao Wang, Zhen Dong, Yonghui Zhao, Yongqiang Zheng, Jia Lian, Hongkai Jin, Yi J Orthop Surg Res Research Article BACKGROUND: To evaluate the meaning of serum CRP, ESR, and D-Dimer in the diagnosis of prosthetic joint infection. METHODS: In a retrospective study, 101 patients presented with osteoarthritis, PJI, and aseptic loosening were divided into three groups according to the type of operation they received in our department from June 2016 to December 2018: group A, 44 patients treated with primary arthroplasty; group B, 31 PJI patients treated with resection arthroplasty and spacer insertion surgery; group C, 26 aseptic loosening patients treated with revision arthroplasty. Data such as gender, age, preoperative serum CRP, ESR, and D-Dimer level were compared among the three different groups. RESULTS: There are no statistically significant differences when comparing general data such as gender and age in patients from the three different groups. However, Serum CRP level in group B (43.49 ± 10.00 mg/L) is significantly higher than in group A (2.97 ± 0.75 mg/L) and C (4.80 ± 1.26 mg/L). Serum ESR level in group B (49.84 ± 5.48 μg/L) is significantly higher than those in group A (15.28 ± 2.63 μg/L) and C (22.50 ± 3.47 μg/L). Serum D-Dimer level in group B (1.58 ± 0.17 μg/L) is significantly higher than that in group A (0.51 ± 0.50 μg/L), but similar with group C (1.22 ± 0.29 μg/L). There are no statistically significant differences when compared with sensitivity and specificity of CRP, ESR, and D-Dimer in the diagnosis of PJI among patients from the three different groups when D-Dimer > 0.85 μg/L was set as the optimal threshold value for the diagnosis of PJI. CONCLUSION: D-Dimer is not a parameter to distinguish between aseptic loosening and PJI. BioMed Central 2019-11-29 /pmc/articles/PMC6884846/ /pubmed/31783874 http://dx.doi.org/10.1186/s13018-019-1461-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Huang, Jincheng Zhang, Yongchao Wang, Zhen Dong, Yonghui Zhao, Yongqiang Zheng, Jia Lian, Hongkai Jin, Yi The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening |
title | The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening |
title_full | The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening |
title_fullStr | The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening |
title_full_unstemmed | The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening |
title_short | The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening |
title_sort | serum level of d-dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884846/ https://www.ncbi.nlm.nih.gov/pubmed/31783874 http://dx.doi.org/10.1186/s13018-019-1461-x |
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