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Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14(ARF), and TAU3 transcript expression and contribute to cognitive decline

The accumulation of senescent cells in tissues is causally linked to the development of several age-related diseases; the removal of senescent glial cells in animal models prevents Tau accumulation and cognitive decline. Senescent cells can arise through several distinct mechanisms; one such mechani...

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Detalles Bibliográficos
Autores principales:	Lye, Jed J., Latorre, Eva, Lee, Ben P., Bandinelli, Stefania, Holley, Janet E., Gutowski, Nicholas J., Ferrucci, Luigi, Harries, Lorna W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885035/ https://www.ncbi.nlm.nih.gov/pubmed/31654269 http://dx.doi.org/10.1007/s11357-019-00100-3

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