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Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum

The resurgence of cases of Zika virus (ZIKV) infection, accompanied by epidemic of microcephaly in Brazil, has aroused worldwide interest in understanding the biological mechanisms of the virus that allow patient management and the viral dissemination control. Colostrum and human milk are possible s...

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Autores principales: de Quental, Ocilma B., França, Eduardo L., Honório-França, Adenilda C., Morais, Tassiane C., Daboin, Blanca E. G., Bezerra, Italla M. P., Komninakis, Shirley V., de Abreu, Luiz C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885239/
https://www.ncbi.nlm.nih.gov/pubmed/31828175
http://dx.doi.org/10.1155/2019/9020519
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author de Quental, Ocilma B.
França, Eduardo L.
Honório-França, Adenilda C.
Morais, Tassiane C.
Daboin, Blanca E. G.
Bezerra, Italla M. P.
Komninakis, Shirley V.
de Abreu, Luiz C.
author_facet de Quental, Ocilma B.
França, Eduardo L.
Honório-França, Adenilda C.
Morais, Tassiane C.
Daboin, Blanca E. G.
Bezerra, Italla M. P.
Komninakis, Shirley V.
de Abreu, Luiz C.
author_sort de Quental, Ocilma B.
collection PubMed
description The resurgence of cases of Zika virus (ZIKV) infection, accompanied by epidemic of microcephaly in Brazil, has aroused worldwide interest in understanding the biological mechanisms of the virus that allow patient management and the viral dissemination control. Colostrum and human milk are possible sources of virus spread. Therefore, the objective of this study was to analyze the repercussions of ZIKV infection on rheological parameters and inflammatory cytokines of colostrum. The prospective cohort study included 40 puerperal donors of colostrum, divided into 2 groups: control (without ZIKV infection, n = 20) and a group infected with ZIKV during the gestational period (n = 20). Analyses were performed for the detection of ZIKV by polymerase chain reaction (PCR). In addition to obtaining the rheological parameters and quantification of IL-10 and IL-6 cytokines by flow cytometry, ZIKV and other flaviviruses were not detected in colostrum. However, maternal infection reflected increased viscosity, decreased levels of IL-10, and elevated levels of IL-6. The higher viscosity may represent a mechanical barrier that hinders the spread of the virus. The lower levels of anti-inflammatory mediators and higher inflammatory cytokines may possibly alter the viscosity, and it seems the higher viscosity represents a possible mechanism of adaptation of breastfeeding against a response to ZIKV.
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spelling pubmed-68852392019-12-11 Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum de Quental, Ocilma B. França, Eduardo L. Honório-França, Adenilda C. Morais, Tassiane C. Daboin, Blanca E. G. Bezerra, Italla M. P. Komninakis, Shirley V. de Abreu, Luiz C. J Immunol Res Research Article The resurgence of cases of Zika virus (ZIKV) infection, accompanied by epidemic of microcephaly in Brazil, has aroused worldwide interest in understanding the biological mechanisms of the virus that allow patient management and the viral dissemination control. Colostrum and human milk are possible sources of virus spread. Therefore, the objective of this study was to analyze the repercussions of ZIKV infection on rheological parameters and inflammatory cytokines of colostrum. The prospective cohort study included 40 puerperal donors of colostrum, divided into 2 groups: control (without ZIKV infection, n = 20) and a group infected with ZIKV during the gestational period (n = 20). Analyses were performed for the detection of ZIKV by polymerase chain reaction (PCR). In addition to obtaining the rheological parameters and quantification of IL-10 and IL-6 cytokines by flow cytometry, ZIKV and other flaviviruses were not detected in colostrum. However, maternal infection reflected increased viscosity, decreased levels of IL-10, and elevated levels of IL-6. The higher viscosity may represent a mechanical barrier that hinders the spread of the virus. The lower levels of anti-inflammatory mediators and higher inflammatory cytokines may possibly alter the viscosity, and it seems the higher viscosity represents a possible mechanism of adaptation of breastfeeding against a response to ZIKV. Hindawi 2019-11-15 /pmc/articles/PMC6885239/ /pubmed/31828175 http://dx.doi.org/10.1155/2019/9020519 Text en Copyright © 2019 Ocilma B. de Quental et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
de Quental, Ocilma B.
França, Eduardo L.
Honório-França, Adenilda C.
Morais, Tassiane C.
Daboin, Blanca E. G.
Bezerra, Italla M. P.
Komninakis, Shirley V.
de Abreu, Luiz C.
Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum
title Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum
title_full Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum
title_fullStr Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum
title_full_unstemmed Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum
title_short Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum
title_sort zika virus alters the viscosity and cytokines profile in human colostrum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885239/
https://www.ncbi.nlm.nih.gov/pubmed/31828175
http://dx.doi.org/10.1155/2019/9020519
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