Cargando…

Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats

Curcumin is a natural polyphenolic compound widely known to have antioxidant, anti-inflammatory, and antiapoptotic properties. In the present study, we explored the neuroprotective effect of curcumin against lipopolysaccharide- (LPS-) induced reactive oxygen species- (ROS-) mediated neuroinflammatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Muhammad Sohail, Muhammad, Tahir, Ikram, Muhammad, Kim, Myeong Ok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885271/ https://www.ncbi.nlm.nih.gov/pubmed/31827700 http://dx.doi.org/10.1155/2019/7860650

Ejemplares similares

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling
por: Muhammad, Tahir, et al.
Publicado: (2019)

Melatonin as a Potential Regulator of Oxidative Stress, and Neuroinflammation: Mechanisms and Implications for the Management of Brain Injury-Induced Neurodegeneration
por: Ikram, Muhammad, et al.
Publicado: (2021)

Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling
por: Ikram, Muhammad, et al.
Publicado: (2019)

Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway
por: Badshah, Haroon, et al.
Publicado: (2016)

Inhibition of JNK Alleviates Chronic Hypoperfusion-Related Ischemia Induces Oxidative Stress and Brain Degeneration via Nrf2/HO-1 and NF-κB Signaling
por: Khan, Muhammad Sohail, et al.
Publicado: (2020)

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain
por: Khan, Amjad, et al.
Publicado: (2018)

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains
por: Badshah, Haroon, et al.
Publicado: (2019)

Caffeine Modulates Cadmium-Induced Oxidative Stress, Neuroinflammation, and Cognitive Impairments by Regulating Nrf-2/HO-1 In Vivo and In Vitro
por: Khan, Amjad, et al.
Publicado: (2019)

Pharmacological Inhibition of Spleen Tyrosine Kinase Suppressed Neuroinflammation and Cognitive Dysfunction in LPS-Induced Neurodegeneration Model
por: Kim, Min Woo, et al.
Publicado: (2022)

Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling
por: Rehman, Shafiq Ur, et al.
Publicado: (2019)

Metformin attenuate PTZ-induced apoptotic neurodegeneration in human cortical neuronal cells
por: Bibi, Fehmida, et al.
Publicado: (2017)

Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative
por: Ullah, Rahim, et al.
Publicado: (2020)

Friedelin Attenuates Neuronal Dysfunction and Memory Impairment by Inhibition of the Activated JNK/NF-κB Signalling Pathway in Scopolamine-Induced Mice Model of Neurodegeneration
por: Sandhu, Marva, et al.
Publicado: (2022)

Phytomedicine-Based Potent Antioxidant, Fisetin Protects CNS-Insult LPS-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment
por: Ahmad, Ashfaq, et al.
Publicado: (2019)

Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain
por: Shah, Shahid Ali, et al.
Publicado: (2016)

Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons
por: Ullah, Ikram, et al.
Publicado: (2012)

Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway
por: Mostafa, Rasha E., et al.
Publicado: (2023)

Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Brain
por: Ullah, Najeeb, et al.
Publicado: (2011)

Pathology, Risk Factors, and Oxidative Damage Related to Type 2 Diabetes-Mediated Alzheimer's Disease and the Rescuing Effects of the Potent Antioxidant Anthocyanin
por: Khan, Muhammad Sohail, et al.
Publicado: (2021)

Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain
por: Shah, S A, et al.
Publicado: (2014)

Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment
por: Ahmad, Sareer, et al.
Publicado: (2021)

Sulfated Chitosan Oligosaccharides Suppress LPS-Induced NO Production via JNK and NF-κB Inactivation
por: Kim, Jung-Hyun, et al.
Publicado: (2014)

Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury
por: Xiao, Zhongxiang, et al.
Publicado: (2019)

Iron, Neuroinflammation and Neurodegeneration
por: Ward, Roberta J., et al.
Publicado: (2022)

Nicotinamide Improves Functional Recovery via Regulation of the RAGE/JNK/NF-κB Signaling Pathway after Brain Injury
por: Alam, Sayed Ibrar, et al.
Publicado: (2019)

Systematic Review of the Common Pathophysiological Mechanisms in COVID-19 and Neurodegeneration: The Role of Bioactive Compounds and Natural Antioxidants
por: Choe, Kyonghwan, et al.
Publicado: (2022)

17β-Estradiol Modulates SIRT1 and Halts Oxidative Stress-Mediated Cognitive Impairment in a Male Aging Mouse Model
por: Khan, Mehtab, et al.
Publicado: (2019)

Alpha-Linolenic Acid Impedes Cadmium-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration in Mouse Brain
por: Alam, Sayed-Ibrar, et al.
Publicado: (2021)

Gut Microbiota, Its Role in Induction of Alzheimer’s Disease Pathology, and Possible Therapeutic Interventions: Special Focus on Anthocyanins
por: Khan, Muhammad Sohail, et al.
Publicado: (2020)

Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the Role of Nrf-2 and A2AR Signaling
por: Ikram, Muhammad, et al.
Publicado: (2020)

Nicotinamide Ameliorates Amyloid Beta-Induced Oxidative Stress-Mediated Neuroinflammation and Neurodegeneration in Adult Mouse Brain
por: Rehman, Inayat Ur, et al.
Publicado: (2021)

Inhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury [Corrigendum]
Publicado: (2022)

Ibrutinib attenuated DSS-induced ulcerative colitis, oxidative stress, and the inflammatory cascade by modulating the PI3K/Akt and JNK/NF-κB pathways
por: Hao, Liangliang, et al.
Publicado: (2022)

Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-κB pathway
por: Yu, T., et al.
Publicado: (2019)

Isodorsmanin A Prevents Inflammatory Response in LPS-Stimulated Macrophages by Inhibiting the JNK and NF-κB Signaling Pathways
por: Chung, You Chul, et al.
Publicado: (2023)

Terpenoids from Abies holophylla Attenuate LPS-Induced Neuroinflammation in Microglial Cells by Suppressing the JNK-Related Signaling Pathway
por: Subedi, Lalita, et al.
Publicado: (2021)

Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions
por: Ikram, Muhammad, et al.
Publicado: (2021)

Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway
por: Zhou, Ran, et al.
Publicado: (2023)

Succinamide Derivatives Ameliorate Neuroinflammation and Oxidative Stress in Scopolamine-Induced Neurodegeneration
por: Iqbal, Sumbal, et al.
Publicado: (2020)

CD38 in Neurodegeneration and Neuroinflammation
por: Guerreiro, Serge, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q4ms0q94k0gt2kerel79m3i14s