Role of the microbiome in occurrence, development and treatment of pancreatic cancer

Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflamm...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yicheng, Yang, Gang, You, Lei, Yang, Jinshou, Feng, Mengyu, Qiu, Jiangdong, Zhao, Fangyu, Liu, Yueze, Cao, Zhe, Zheng, Lianfang, Zhang, Taiping, Zhao, Yupei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885316/
https://www.ncbi.nlm.nih.gov/pubmed/31785619
http://dx.doi.org/10.1186/s12943-019-1103-2
_version_ 1783474717884153856
author Wang, Yicheng
Yang, Gang
You, Lei
Yang, Jinshou
Feng, Mengyu
Qiu, Jiangdong
Zhao, Fangyu
Liu, Yueze
Cao, Zhe
Zheng, Lianfang
Zhang, Taiping
Zhao, Yupei
author_facet Wang, Yicheng
Yang, Gang
You, Lei
Yang, Jinshou
Feng, Mengyu
Qiu, Jiangdong
Zhao, Fangyu
Liu, Yueze
Cao, Zhe
Zheng, Lianfang
Zhang, Taiping
Zhao, Yupei
author_sort Wang, Yicheng
collection PubMed
description Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflammation and immunomodulation. Potential therapeutic and diagnostic applications of microbiomes are also discussed. For example, microbiomes may serve as diagnostic markers for pancreatic cancer, and may also play an important role in determining the efficacies of treatments such as chemo- and immunotherapies. Future studies will provide additional insights into the various roles of microbiomes in pancreatic cancer.
format Online
Article
Text
id pubmed-6885316
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-68853162019-12-03 Role of the microbiome in occurrence, development and treatment of pancreatic cancer Wang, Yicheng Yang, Gang You, Lei Yang, Jinshou Feng, Mengyu Qiu, Jiangdong Zhao, Fangyu Liu, Yueze Cao, Zhe Zheng, Lianfang Zhang, Taiping Zhao, Yupei Mol Cancer Review Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflammation and immunomodulation. Potential therapeutic and diagnostic applications of microbiomes are also discussed. For example, microbiomes may serve as diagnostic markers for pancreatic cancer, and may also play an important role in determining the efficacies of treatments such as chemo- and immunotherapies. Future studies will provide additional insights into the various roles of microbiomes in pancreatic cancer. BioMed Central 2019-12-01 /pmc/articles/PMC6885316/ /pubmed/31785619 http://dx.doi.org/10.1186/s12943-019-1103-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wang, Yicheng
Yang, Gang
You, Lei
Yang, Jinshou
Feng, Mengyu
Qiu, Jiangdong
Zhao, Fangyu
Liu, Yueze
Cao, Zhe
Zheng, Lianfang
Zhang, Taiping
Zhao, Yupei
Role of the microbiome in occurrence, development and treatment of pancreatic cancer
title Role of the microbiome in occurrence, development and treatment of pancreatic cancer
title_full Role of the microbiome in occurrence, development and treatment of pancreatic cancer
title_fullStr Role of the microbiome in occurrence, development and treatment of pancreatic cancer
title_full_unstemmed Role of the microbiome in occurrence, development and treatment of pancreatic cancer
title_short Role of the microbiome in occurrence, development and treatment of pancreatic cancer
title_sort role of the microbiome in occurrence, development and treatment of pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885316/
https://www.ncbi.nlm.nih.gov/pubmed/31785619
http://dx.doi.org/10.1186/s12943-019-1103-2
work_keys_str_mv AT wangyicheng roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT yanggang roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT youlei roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT yangjinshou roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT fengmengyu roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT qiujiangdong roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT zhaofangyu roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT liuyueze roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT caozhe roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT zhenglianfang roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT zhangtaiping roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer
AT zhaoyupei roleofthemicrobiomeinoccurrencedevelopmentandtreatmentofpancreaticcancer

Ejemplares similares