Cargando…

Colchicine-like β-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity

OBJECTIVE(S): In this study a series of novel colchicine-like β-acetamidoketones was designed and synthesized as potential tubulin inhibitors MATERIALS AND METHODS: The cytotoxicity of the novel synthesized β-acetamidoketones was assessed against two cancerous cell lines including MCF-7 (human breas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karimikia, Ehsan, Behravan, Javad, Zarghi, Afshin, Ghandadi, Morteza, Omid Malayeri, Sina, Ghodsi, Razieh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mashhad University of Medical Sciences 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885397/ https://www.ncbi.nlm.nih.gov/pubmed/31998454 http://dx.doi.org/10.22038/ijbms.2019.34760.8242

Ejemplares similares

Synthesis and biological evaluation of oxazinonaphthalene-3-one derivatives as potential anticancer agents and tubulin inhibitors
por: Mirzaei, Salimeh, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of4-(Imidazolylmethyl)-2-(4-methylsulfonyl phenyl)-Quinoline Derivatives as Selective COX-2 Inhibitors and In-vitro Anti-breast Cancer Agents
por: Ghodsi, Razieh, et al.
Publicado: (2016)

Synthesis, Characterization and In-vitro Evaluation of Novel Naphthoquinone Derivatives and Related Imines: Identification of New Anticancer Leads
por: Golmakaniyoon, Sima, et al.
Publicado: (2019)

Taxol-induced rose microtubule polymerization in vitro and its inhibition by colchicine
Publicado: (1984)

Comparative proteomics study of proteins involved in induction of higher rates of cell death in mitoxantrone-resistant breast cancer cells MCF-7/MX exposed to TNF-α
por: Norouzi, Saeed, et al.
Publicado: (2020)

Design, synthesis, and biological evaluation of novel 5,6,7-trimethoxy quinolines as potential anticancer agents and tubulin polymerization inhibitors
por: Mirzaei, Salimeh, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of New 5,5-Diarylhydantoin Derivatives as Selective Cyclooxygenase-2 Inhibitors
por: Zarghi, Afshin, et al.
Publicado: (2011)

Inhibition of Akt phosphorylation attenuates resistance to TNF-α cytotoxic effects in MCF-7 cells, but not in their doxorubicin resistant derivatives
por: Ghandadi, Morteza, et al.
Publicado: (2016)

Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine
Publicado: (1984)

An Immunoinformatic Strategy to Develop New Mycobacterium tuberculosis Multi-epitope Vaccine
por: Ghandadi, Morteza
Publicado: (2022)

Design, Synthesis, Docking Study, and Biological Evaluation of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide Derivatives as Anti-HIV-1 and Antibacterial Agents.
por: Abdollahi, Omid, et al.
Publicado: (2022)

Colchicine-binding protein of the liver. Its characterization and relation to microtubules
Publicado: (1975)

Novel Colchicine Analogues Target Mitochondrial PT Pores Using Free Tubulins and Induce ROS-Mediated Apoptosis in Cancerous Lymphocytes
por: Aghvami, Marjan, et al.
Publicado: (2018)

Microtubules and beta cell function: effect of colchicine on microtubules and insulin secretion in vitro by mouse beta cells
Publicado: (1982)

Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents
por: Lu, Yan, et al.
Publicado: (2014)

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
por: Majcher, Urszula, et al.
Publicado: (2018)

Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin
por: Ma, Rundi, et al.
Publicado: (2007)

Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel
por: Bombuwala, Karunananda, et al.
Publicado: (2006)

Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin
por: Sharma, Ashwani, et al.
Publicado: (2017)

Docking experiments suggest that gloriosine has microtubule-targeting properties similar to colchicine
por: Misra, Ankita, et al.
Publicado: (2023)

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine
por: Dhyani, Praveen, et al.
Publicado: (2022)

Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents
por: Tomar, Vartika, et al.
Publicado: (2019)

Design, Synthesis, and Biological Evaluation of New 2-Phenyl-4H-chromen-4-one Derivatives as Selective Cyclooxygenase-2 Inhibitors
por: Zarghi, Afshin, et al.
Publicado: (2015)

The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis
por: Kim, Sung-Kuk, et al.
Publicado: (2013)

Introducing variability in targeting the microtubules: Review of current mechanisms and future directions in colchicine therapy
por: Forkosh, Esther, et al.
Publicado: (2020)

First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent
por: Borys, Filip, et al.
Publicado: (2023)

Microtubule-associated proteins-dependent colchicine stability of acetylated cold-labile brain microtubules from the Atlantic cod, Gadus morhua
Publicado: (1991)

Fluorescein colchicine. Synthesis, purification, and biological activity
Publicado: (1978)

3D-QSAR-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Identification of Tubulin Inhibitors with Potential Anticancer Activity
por: Mirzaei, Salimeh, et al.
Publicado: (2021)

Corrigendum to “3D-QSAR-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Identification of Tubulin Inhibitors with Potential Anticancer Activity”
por: Mirzaei, Salimeh, et al.
Publicado: (2022)

MCAK associates with the tips of polymerizing microtubules
por: Moore, Ayana T., et al.
Publicado: (2005)

THE ROLE OF THREE CYTOPLASMIC FIBERS IN BHK-21 CELL MOTILITY : I. Microtubules and the Effects of Colchicine
por: Goldman, Robert D.
Publicado: (1971)

INCOMPLETE MICROTUBULES OBSERVED IN MAMMALIAN BLOOD PLATELETS DURING MICROTUBULE POLYMERIZATION
por: Behnke, O.
Publicado: (1967)

Bioactive glass-collagen/poly (glycolic acid) scaffold nanoparticles exhibit improved biological properties and enhance osteogenic lineage differentiation of mesenchymal stem cells
por: Toosi, Shirin, et al.
Publicado: (2022)

Colchicine
por: Ben-Chetrit, Eldad
Publicado: (2018)

Flagellar microtubule dynamics in Chlamydomonas: cytochalasin D induces periods of microtubule shortening and elongation; and colchicine induces disassembly of the distal, but not proximal, half of the flagellum
Publicado: (1992)

Design, eco-friendly synthesis, molecular modeling and anticancer evaluation of thiazol-5(4H)-ones as potential tubulin polymerization inhibitors targeting the colchicine binding site
por: El-Naggar, Abeer M., et al.
Publicado: (2020)

Microtubules and protein secretion in rat lacrimal glands: localization of short-term effects of colchicine on the secretory process
Publicado: (1982)

The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips
por: Chen, Xiuzhen, et al.
Publicado: (2023)

Colchicine Ameliorates 5-Fluorouracil-Induced Cardiotoxicity in Rats
por: Safarpour, Soheila, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1klibd1o0971bpbrvuo7pl4f1s