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Refractory epilepsy and nonadherence to drug treatment

In patients with epilepsy, nonadherence to agreed antiepileptic drug (AED) treatment may result in seizure relapse, and at worst sudden unexpected death. The aim of this study was to examine the extent of both unintentional and intentional nonadherence among Norwegian patients with refractory epilep...

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Autores principales: Henning, Oliver, Lossius, Morten I., Lima, Maren, Mevåg, Morten, Villagran, Antonia, Nakken, Karl O., Johannessen Landmark, Cecilie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885656/
https://www.ncbi.nlm.nih.gov/pubmed/31819918
http://dx.doi.org/10.1002/epi4.12367
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author Henning, Oliver
Lossius, Morten I.
Lima, Maren
Mevåg, Morten
Villagran, Antonia
Nakken, Karl O.
Johannessen Landmark, Cecilie
author_facet Henning, Oliver
Lossius, Morten I.
Lima, Maren
Mevåg, Morten
Villagran, Antonia
Nakken, Karl O.
Johannessen Landmark, Cecilie
author_sort Henning, Oliver
collection PubMed
description In patients with epilepsy, nonadherence to agreed antiepileptic drug (AED) treatment may result in seizure relapse, and at worst sudden unexpected death. The aim of this study was to examine the extent of both unintentional and intentional nonadherence among Norwegian patients with refractory epilepsy and try to identify possible risk factors. At the National Centre for Epilepsy in Norway, 333 consecutive adult in‐ and outpatients with refractory epilepsy participated in an anonymous survey about adherence to drug treatment. Twenty‐two percentages admitted that they sometimes or often forgot to take their drugs as scheduled, and 19% reported that they, rarely, sometimes or often intentionally did not follow the AED treatment plan agreed upon with their physician. Young age and depression were significantly correlated with unintentional nonadherence. Intentional nonadherence was associated with young age (36 years or younger). We found nonadherence not to be associated with any specific AED. In conclusion, about one‐fifth of patients with refractory epilepsy admitted that they did not adhere to the agreed drug treatment plan, either intentionally or unintentionally. Measures to reduce nonadherence in this patient group may improve seizure control and should be tailored to address both unintentional and intentional lack of adherence.
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spelling pubmed-68856562019-12-09 Refractory epilepsy and nonadherence to drug treatment Henning, Oliver Lossius, Morten I. Lima, Maren Mevåg, Morten Villagran, Antonia Nakken, Karl O. Johannessen Landmark, Cecilie Epilepsia Open Short Research Article In patients with epilepsy, nonadherence to agreed antiepileptic drug (AED) treatment may result in seizure relapse, and at worst sudden unexpected death. The aim of this study was to examine the extent of both unintentional and intentional nonadherence among Norwegian patients with refractory epilepsy and try to identify possible risk factors. At the National Centre for Epilepsy in Norway, 333 consecutive adult in‐ and outpatients with refractory epilepsy participated in an anonymous survey about adherence to drug treatment. Twenty‐two percentages admitted that they sometimes or often forgot to take their drugs as scheduled, and 19% reported that they, rarely, sometimes or often intentionally did not follow the AED treatment plan agreed upon with their physician. Young age and depression were significantly correlated with unintentional nonadherence. Intentional nonadherence was associated with young age (36 years or younger). We found nonadherence not to be associated with any specific AED. In conclusion, about one‐fifth of patients with refractory epilepsy admitted that they did not adhere to the agreed drug treatment plan, either intentionally or unintentionally. Measures to reduce nonadherence in this patient group may improve seizure control and should be tailored to address both unintentional and intentional lack of adherence. John Wiley and Sons Inc. 2019-11-06 /pmc/articles/PMC6885656/ /pubmed/31819918 http://dx.doi.org/10.1002/epi4.12367 Text en © 2019 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Short Research Article
Henning, Oliver
Lossius, Morten I.
Lima, Maren
Mevåg, Morten
Villagran, Antonia
Nakken, Karl O.
Johannessen Landmark, Cecilie
Refractory epilepsy and nonadherence to drug treatment
title Refractory epilepsy and nonadherence to drug treatment
title_full Refractory epilepsy and nonadherence to drug treatment
title_fullStr Refractory epilepsy and nonadherence to drug treatment
title_full_unstemmed Refractory epilepsy and nonadherence to drug treatment
title_short Refractory epilepsy and nonadherence to drug treatment
title_sort refractory epilepsy and nonadherence to drug treatment
topic Short Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885656/
https://www.ncbi.nlm.nih.gov/pubmed/31819918
http://dx.doi.org/10.1002/epi4.12367
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