Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise

We report a 35-year-old man who suffered from recurrent macroscopic haematuria after intensive exercise. One episode was associated with bilateral loin (flank) pain and severe acute kidney injury. His kidney biopsy revealed an atypical anti-glomerular basement membrane (GBM) disease typified by brig...

Descripción completa

Detalles Bibliográficos
Autores principales: Le Flecher, Arnaud, Viallet, Nicolas, Hebmann, Delphine, Chauveau, Bertrand, Vacher Coponat, Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Glomerulonephritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885666/
https://www.ncbi.nlm.nih.gov/pubmed/31807293
http://dx.doi.org/10.1093/ckj/sfz044
_version_ 1783474766181564416
author Le Flecher, Arnaud
Viallet, Nicolas
Hebmann, Delphine
Chauveau, Bertrand
Vacher Coponat, Henri
author_facet Le Flecher, Arnaud
Viallet, Nicolas
Hebmann, Delphine
Chauveau, Bertrand
Vacher Coponat, Henri
author_sort Le Flecher, Arnaud
collection PubMed
description We report a 35-year-old man who suffered from recurrent macroscopic haematuria after intensive exercise. One episode was associated with bilateral loin (flank) pain and severe acute kidney injury. His kidney biopsy revealed an atypical anti-glomerular basement membrane (GBM) disease typified by bright linear GBM staining for monotypic immunoglobulin G but without a diffuse crescentic phenotype and no circulating anti-GBM antibody. Outcome was spontaneously favourable. The patient had no recurrence or urine abnormality without running. The original presentation emphasized that exercise could reveal an underlying glomerulopathy.
format Online
Article
Text
id pubmed-6885666
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-68856662019-12-05 Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise Le Flecher, Arnaud Viallet, Nicolas Hebmann, Delphine Chauveau, Bertrand Vacher Coponat, Henri Clin Kidney J Glomerulonephritis We report a 35-year-old man who suffered from recurrent macroscopic haematuria after intensive exercise. One episode was associated with bilateral loin (flank) pain and severe acute kidney injury. His kidney biopsy revealed an atypical anti-glomerular basement membrane (GBM) disease typified by bright linear GBM staining for monotypic immunoglobulin G but without a diffuse crescentic phenotype and no circulating anti-GBM antibody. Outcome was spontaneously favourable. The patient had no recurrence or urine abnormality without running. The original presentation emphasized that exercise could reveal an underlying glomerulopathy. Oxford University Press 2019-04-23 /pmc/articles/PMC6885666/ /pubmed/31807293 http://dx.doi.org/10.1093/ckj/sfz044 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Glomerulonephritis
Le Flecher, Arnaud
Viallet, Nicolas
Hebmann, Delphine
Chauveau, Bertrand
Vacher Coponat, Henri
Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise
title Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise
title_full Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise
title_fullStr Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise
title_full_unstemmed Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise
title_short Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise
title_sort atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise
topic Glomerulonephritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885666/
https://www.ncbi.nlm.nih.gov/pubmed/31807293
http://dx.doi.org/10.1093/ckj/sfz044
work_keys_str_mv AT leflecherarnaud atypicalantiglomerularbasementmembranediseasepresentingasmacroscopichaematurialoinpainandacutekidneyinjuryafterintensiveexercise
AT vialletnicolas atypicalantiglomerularbasementmembranediseasepresentingasmacroscopichaematurialoinpainandacutekidneyinjuryafterintensiveexercise
AT hebmanndelphine atypicalantiglomerularbasementmembranediseasepresentingasmacroscopichaematurialoinpainandacutekidneyinjuryafterintensiveexercise
AT chauveaubertrand atypicalantiglomerularbasementmembranediseasepresentingasmacroscopichaematurialoinpainandacutekidneyinjuryafterintensiveexercise
AT vachercoponathenri atypicalantiglomerularbasementmembranediseasepresentingasmacroscopichaematurialoinpainandacutekidneyinjuryafterintensiveexercise

Ejemplares similares