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Tau deletion reduces plaque‐associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease

In Alzheimer's disease, BACE1 protease initiates the amyloidogenic processing of amyloid precursor protein (APP) that eventually results in synthesis of β‐amyloid (Aβ) peptide. Aβ deposition in turn causes accumulation of BACE1 in plaque‐associated dystrophic neurites, thereby potentiating prog...

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Detalles Bibliográficos
Autores principales:	Peters, Finn, Salihoglu, Hazal, Pratsch, Katrin, Herzog, Etienne, Pigoni, Martina, Sgobio, Carmelo, Lichtenthaler, Stefan F, Neumann, Ulf, Herms, Jochen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885735/ https://www.ncbi.nlm.nih.gov/pubmed/31701556 http://dx.doi.org/10.15252/embj.2019102345

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