New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases

Respiratory diseases are one of the most common pediatric diseases in clinical practice. Their pathogenesis, diagnosis, and treatment are thus worthy of further investigation. The nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) signaling axis is a multiple organ protection c...

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Autores principales: Zhang, Xueyan, Ding, Ming, Zhu, Ping, Huang, Huanlei, Zhuang, Quan, Shen, Jie, Cai, Yufeng, Zhao, Mingyi, He, Qingnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885770/
https://www.ncbi.nlm.nih.gov/pubmed/31827672
http://dx.doi.org/10.1155/2019/3214196
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author Zhang, Xueyan
Ding, Ming
Zhu, Ping
Huang, Huanlei
Zhuang, Quan
Shen, Jie
Cai, Yufeng
Zhao, Mingyi
He, Qingnan
author_facet Zhang, Xueyan
Ding, Ming
Zhu, Ping
Huang, Huanlei
Zhuang, Quan
Shen, Jie
Cai, Yufeng
Zhao, Mingyi
He, Qingnan
author_sort Zhang, Xueyan
collection PubMed
description Respiratory diseases are one of the most common pediatric diseases in clinical practice. Their pathogenesis, diagnosis, and treatment are thus worthy of further investigation. The nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) signaling axis is a multiple organ protection chain that protects against oxidative stress injury. This signaling axis regulates anti-inflammation and antioxidation by regulating calcium ions, mitochondrial oxidative stress, autophagy, ferroptosis, pyroptosis, apoptosis, alkaliptosis, and clockophagy. This review presents an overview of the role of the Nrf2/HO-1 signaling axis in the pathogenesis of pediatric respiratory diseases and the latest research progress on this subject. Overall, the Nrf2/HO-1 signaling axis has an important clinical value in pediatric respiratory diseases, and its protective effect needs further exploration.
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spelling pubmed-68857702019-12-11 New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases Zhang, Xueyan Ding, Ming Zhu, Ping Huang, Huanlei Zhuang, Quan Shen, Jie Cai, Yufeng Zhao, Mingyi He, Qingnan Oxid Med Cell Longev Review Article Respiratory diseases are one of the most common pediatric diseases in clinical practice. Their pathogenesis, diagnosis, and treatment are thus worthy of further investigation. The nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) signaling axis is a multiple organ protection chain that protects against oxidative stress injury. This signaling axis regulates anti-inflammation and antioxidation by regulating calcium ions, mitochondrial oxidative stress, autophagy, ferroptosis, pyroptosis, apoptosis, alkaliptosis, and clockophagy. This review presents an overview of the role of the Nrf2/HO-1 signaling axis in the pathogenesis of pediatric respiratory diseases and the latest research progress on this subject. Overall, the Nrf2/HO-1 signaling axis has an important clinical value in pediatric respiratory diseases, and its protective effect needs further exploration. Hindawi 2019-11-19 /pmc/articles/PMC6885770/ /pubmed/31827672 http://dx.doi.org/10.1155/2019/3214196 Text en Copyright © 2019 Xueyan Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Xueyan
Ding, Ming
Zhu, Ping
Huang, Huanlei
Zhuang, Quan
Shen, Jie
Cai, Yufeng
Zhao, Mingyi
He, Qingnan
New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases
title New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases
title_full New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases
title_fullStr New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases
title_full_unstemmed New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases
title_short New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases
title_sort new insights into the nrf-2/ho-1 signaling axis and its application in pediatric respiratory diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885770/
https://www.ncbi.nlm.nih.gov/pubmed/31827672
http://dx.doi.org/10.1155/2019/3214196
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