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Inhibition of the Nrf2-TrxR Axis Sensitizes the Drug-Resistant Chronic Myelogenous Leukemia Cell Line K562/G01 to Imatinib Treatments

Nuclear factor erythroid 2-related factor 2 (Nrf2) is involved in tumor drug resistance, but its role in imatinib resistance of chronic myeloid leukemia (CML) remains elusive. We aimed to investigate the effects of Nrf2 on drug sensitivity, thioredoxin reductase (TrxR) expression, reactive oxygen sp...

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Detalles Bibliográficos
Autores principales:	Xu, Lianrong, Zhao, Yan, Pan, Fei, Zhu, Mengxia, Yao, Liqin, Liu, Yan, Feng, Jiangfang, Xiong, Jie, Chen, Xiuhua, Ren, Fanggang, Tan, Yanhong, Wang, Hongwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885806/ https://www.ncbi.nlm.nih.gov/pubmed/31828114 http://dx.doi.org/10.1155/2019/6502793

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