Cargando…

A novel intraperitoneal therapy for gastric cancer with DFP‐10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model

PURPOSE: In advanced gastric cancer, peritoneal dissemination is a life‐threatening mode of metastasis. Since the treatment options with conventional chemotherapy remain limited, any novel therapeutic strategy that could control such metastasis would improve the outcome of treatment. We recently dev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ando, Hidenori, Fukushima, Masakazu, Eshima, Kiyoshi, Hasui, Taichi, Shimizu, Taro, Ishima, Yu, Huang, Cheng‐Long, Wada, Hiromi, Ishida, Tatsuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885878/ https://www.ncbi.nlm.nih.gov/pubmed/31609087 http://dx.doi.org/10.1002/cam4.2598

Ejemplares similares

Anticancer activity of the intraperitoneal-delivered DFP-10825, the cationic liposome-conjugated RNAi molecule targeting thymidylate synthase, on peritoneal disseminated ovarian cancer xenograft model
por: Iizuka, Kenzo, et al.
Publicado: (2018)

Development of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents
por: Fukushima, Masakazu, et al.
Publicado: (2017)

A novel polyethylene glycol (PEG)‐drug conjugate of Venetoclax, a Bcl‐2 inhibitor, for treatment of acute myeloid leukemia (AML)
por: Ando, Hidenori, et al.
Publicado: (2021)

Doxorubicin Embedded into Nanofibrillated Bacterial Cellulose (NFBC) Produces a Promising Therapeutic Outcome for Peritoneally Metastatic Gastric Cancer in Mice Models via Intraperitoneal Direct Injection
por: Ando, Hidenori, et al.
Publicado: (2021)

Adjuvant Antitumor Immunity Contributes to the Overall Antitumor Effect of Pegylated Liposomal Doxorubicin (Doxil(®)) in C26 Tumor-Bearing Immunocompetent Mice
por: Takayama, Takuma, et al.
Publicado: (2020)

FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages
por: Tachibana, Koki, et al.
Publicado: (2022)

HCC diagnosis DFP report
Publicado: (2021)

Neuroendocrine neoplasm DFP report
Publicado: (2021)

Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model
por: Shimizu, Taro, et al.
Publicado: (2017)

A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma
por: Ando, Hidenori, et al.
Publicado: (2020)

Expression of Thymidylate Synthase in Human Non‐small Cell Lung Cancer
por: Otake, Yosuke, et al.
Publicado: (1999)

The Therapeutic Effect of Human Serum Albumin Dimer-Doxorubicin Complex against Human Pancreatic Tumors
por: Kinoshita, Ryo, et al.
Publicado: (2021)

Database fingerprint (DFP): an approach to represent molecular databases
por: Fernández-de Gortari, Eli, et al.
Publicado: (2017)

Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways
por: Emam, Sherif E., et al.
Publicado: (2018)

A Chromogenic Probe for the Selective Recognition of Sarin and Soman Mimic DFP**
por: El Sayed, Sameh, et al.
Publicado: (2014)

Aminoalcohol-Induced Activation of Organophosphorus Hydrolase (OPH) towards Diisopropylfluorophosphate (DFP)
por: Li, Dandan, et al.
Publicado: (2017)

Improved 3D measurement with a novel preprocessing method in DFP
por: Xiao, Yi, et al.
Publicado: (2017)

Characterization of Cortical Glial Scars in the Diisopropylfluorophosphate (DFP) Rat Model of Epilepsy
por: Gage, Meghan, et al.
Publicado: (2022)

Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities
por: Ikeda, Mayumi, et al.
Publicado: (2019)

Gut dysbiosis following organophosphate, diisopropylfluorophosphate (DFP), intoxication and saracatinib oral administration
por: Gage, Meghan, et al.
Publicado: (2022)

DFP: a Bioconductor package for fuzzy profile identification and gene reduction of microarray data
por: Glez-Peña, Daniel, et al.
Publicado: (2009)

Dynamic Modulation of Thymidylate Synthase Gene Expression and Fluorouracil Sensitivity in Human Colorectal Cancer Cells
por: Wakasa, Kentaro, et al.
Publicado: (2015)

Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness
por: O'Callaghan, James P., et al.
Publicado: (2015)

Establishment of various biliary tract carcinoma cell lines and xenograft models for appropriate preclinical studies
por: Ojima, Hidenori, et al.
Publicado: (2016)

The C-terminus of S. pombe DDK subunit Dfp1 is required for meiosis-specific transcription and cohesin cleavage
por: Le, Anh-Huy, et al.
Publicado: (2013)

Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death
por: Brenet, Alexandre, et al.
Publicado: (2020)

Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats
por: González, Eduardo A., et al.
Publicado: (2021)

RDAU-Net: Based on a Residual Convolutional Neural Network With DFP and CBAM for Brain Tumor Segmentation
por: Wang, Jingjing, et al.
Publicado: (2022)

Peripheral and central effects of NADPH oxidase inhibitor, mitoapocynin, in a rat model of diisopropylfluorophosphate (DFP) toxicity
por: Meyer, Christina, et al.
Publicado: (2023)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

Deferiprone (DFP) Targets Cancer Stem Cell (CSC) Propagation by Inhibiting Mitochondrial Metabolism and Inducing ROS Production
por: Fiorillo, Marco, et al.
Publicado: (2020)

Quantitative Measurement of Thymidylate Synthase and Dihydropyrimidine Dehydrogenase mRNA Level in Gastric Cancer by Real‐time RT‐PCR
por: Fujiwara, Hisataka, et al.
Publicado: (2002)

Effects of intraperitoneal recombinant interleukin-1 beta in intraperitoneal human ovarian cancer xenograft models: comparison with the effects of tumour necrosis factor.
por: Malik, S. T., et al.
Publicado: (1992)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

Successful local regional therapy with topotecan of intraperitoneally growing human ovarian carcinoma xenografts.
por: Pratesi, G., et al.
Publicado: (1995)

Hydrolysis of DFP and the Nerve Agent (S)-Sarin by DFPase Proceeds along Two Different Reaction Pathways: Implications for Engineering Bioscavengers
por: Wymore, Troy, et al.
Publicado: (2014)

Age-dependent behaviors, seizure severity and neuronal damage in response to nerve agents or the organophosphate DFP in immature and adult rats
por: Scholl, Erika A., et al.
Publicado: (2018)

Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness
por: Phillips, Kristin F, et al.
Publicado: (2019)

Author Correction: Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death
por: Brenet, Alexandre, et al.
Publicado: (2021)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_h1sbkml555b8bvecgh4d9232e9