Gasdermin D-mediated hepatocyte pyroptosis expands inflammatory responses that aggravate acute liver failure by upregulating monocyte chemotactic protein 1/CC chemokine receptor-2 to recruit macrophages

BACKGROUND: Massive hepatocyte death is the core event in acute liver failure (ALF). Gasdermin D (GSDMD)-mediated pyroptosis is a type of highly inflammatory cell death. However, the role of hepatocyte pyroptosis and its mechanisms of expanding inflammatory responses in ALF are unclear. AIM: To inve...

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Detalles Bibliográficos
Autores principales: Li, Hong, Zhao, Xue-Ke, Cheng, Yi-Ju, Zhang, Quan, Wu, Jun, Lu, Shuang, Zhang, Wei, Liu, Yang, Zhou, Ming-Yu, Wang, Ya, Yang, Jing, Cheng, Ming-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886019/
https://www.ncbi.nlm.nih.gov/pubmed/31802832
http://dx.doi.org/10.3748/wjg.v25.i44.6527

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