Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of glutamine-deprived cells. However, pancreatic cancers...

Descripción completa

Detalles Bibliográficos
Autores principales: Bott, Alex J., Shen, Jianliang, Tonelli, Claudia, Zhan, Le, Sivaram, Nithya, Jiang, Ya-Ping, Yu, Xufen, Bhatt, Vrushank, Chiles, Eric, Zhong, Hua, Maimouni, Sara, Dai, Weiwei, Velasquez, Stephani, Pan, Ji-An, Muthalagu, Nathiya, Morton, Jennifer, Anthony, Tracy G., Feng, Hui, Lamers, Wouter H., Murphy, Daniel J., Guo, Jessie Yanxiang, Jin, Jian, Crawford, Howard C., Zhang, Lanjing, White, Eileen, Lin, Richard Z., Su, Xiaoyang, Tuveson, David A., Zong, Wei-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886125/
https://www.ncbi.nlm.nih.gov/pubmed/31665640
http://dx.doi.org/10.1016/j.celrep.2019.09.056

Ejemplares similares

Ejemplares similares