eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5′UTR

BACKGROUND: Regulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not fully understood. RESULTS: Here, we show that eIF4A2 is a majo...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilczynska, Ania, Gillen, Sarah L., Schmidt, Tobias, Meijer, Hedda A., Jukes-Jones, Rebekah, Langlais, Claudia, Kopra, Kari, Lu, Wei-Ting, Godfrey, Jack D., Hawley, Benjamin R., Hodge, Kelly, Zanivan, Sara, Cain, Kelvin, Le Quesne, John, Bushell, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886185/
https://www.ncbi.nlm.nih.gov/pubmed/31791371
http://dx.doi.org/10.1186/s13059-019-1857-2

Ejemplares similares

Ejemplares similares