Chemical screen for epigenetic barriers to single allele activation of Oct4

Here we utilized the chromatin in vivo assay (CiA) mouse platform to directly examine the epigenetic barriers impeding the activation of the CiA:Oct4 allele in mouse embryonic fibroblasts (MEF)s when stimulated with a transcription factor. The CiA:Oct4 allele contains an engineered EGFP reporter rep...

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Detalles Bibliográficos
Autores principales: Headley, Kathryn M., Kedziora, Katarzyna M., Alejo, Aidin, Lai, Elianna Zhi-Xiang, Purvis, Jeremy E., Hathaway, Nathaniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886240/
https://www.ncbi.nlm.nih.gov/pubmed/31170660
http://dx.doi.org/10.1016/j.scr.2019.101470

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