Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer

The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal and neoplastic cells. This study is aimed at investigating the differential tissue expression of GALE and its possible association with clinical-pathological parameters and the outcom...

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Detalles Bibliográficos
Autores principales: de Souza, Maria de Fátima Deodato, da Silva Filho, Antônio Felix, de Barros Albuquerque, Amanda Pinheiro, Quirino, Michael Williams Leal, de Souza Albuquerque, Mário Sérgio, Cordeiro, Marina Ferraz, Martins, Mário Rino, da Rocha Pitta, Ivan, Lucena-Araujo, Antônio Roberto, da Rocha Pitta, Maira Galdino, de Melo Rêgo, Moacyr Jesus Barreto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886318/
https://www.ncbi.nlm.nih.gov/pubmed/31827638
http://dx.doi.org/10.1155/2019/6325326
Descripción
Sumario:The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal and neoplastic cells. This study is aimed at investigating the differential tissue expression of GALE and its possible association with clinical-pathological parameters and the outcome of gastric adenocarcinoma patients. Seventy-one patients were evaluated in relation to GALE expression by immunohistochemistry. Our results showed that 48 (67.6%) patients were GALE positive and 23 (32.4%) negative. Positive staining was present on well-differentiated and moderate-differentiated histological grade of gastric adenocarcinomas (p < 0.0001). There was no significant association with outcome parameters (p > 0.05). Besides that, our results corroborated with the validation cohort analysis, where the expression of GALE mRNA was also associated with the histological grade (p < 0.001). These results suggest a possible use of this enzyme as a biomarker for well and moderately differentiated tumors.

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