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Regulatory T Cells in Respiratory Health and Diseases

Respiratory diseases compromise the health of millions of people all over the world and are strongly linked to the immune dysfunction. CD4+FOXP3+ T regulatory cells, also known as Tregs, have a central role maintaining tissue homeostasis during immune responses. Their activity and clinical impact ha...

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Autores principales: Singh, Rani, Alape, Daniel, de Lima, Andrés, Ascanio, Juan, Majid, Adnan, Gangadharan, Sidhu P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886321/
https://www.ncbi.nlm.nih.gov/pubmed/31827925
http://dx.doi.org/10.1155/2019/1907807
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author Singh, Rani
Alape, Daniel
de Lima, Andrés
Ascanio, Juan
Majid, Adnan
Gangadharan, Sidhu P.
author_facet Singh, Rani
Alape, Daniel
de Lima, Andrés
Ascanio, Juan
Majid, Adnan
Gangadharan, Sidhu P.
author_sort Singh, Rani
collection PubMed
description Respiratory diseases compromise the health of millions of people all over the world and are strongly linked to the immune dysfunction. CD4+FOXP3+ T regulatory cells, also known as Tregs, have a central role maintaining tissue homeostasis during immune responses. Their activity and clinical impact have been widely studied in different clinical conditions including autoimmune diseases, inflammatory conditions, and cancer, amongst others. Tregs express transcription factor forkhead box P3 (FOXP3), which allows regulation of the immune response through anti-inflammatory cytokines such as IL-10 or transforming growth factor beta (TGF-β) and direct cell-to-cell interaction. Maintenance of immune tolerance is achieved via modulation of effector CD4+ T helper 1, 2 or 17 (Th1, Th2, Th17) cells by Tregs. This review highlights the recent progress in the understanding of Tregs in different disorders of the respiratory system.
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spelling pubmed-68863212019-12-11 Regulatory T Cells in Respiratory Health and Diseases Singh, Rani Alape, Daniel de Lima, Andrés Ascanio, Juan Majid, Adnan Gangadharan, Sidhu P. Pulm Med Review Article Respiratory diseases compromise the health of millions of people all over the world and are strongly linked to the immune dysfunction. CD4+FOXP3+ T regulatory cells, also known as Tregs, have a central role maintaining tissue homeostasis during immune responses. Their activity and clinical impact have been widely studied in different clinical conditions including autoimmune diseases, inflammatory conditions, and cancer, amongst others. Tregs express transcription factor forkhead box P3 (FOXP3), which allows regulation of the immune response through anti-inflammatory cytokines such as IL-10 or transforming growth factor beta (TGF-β) and direct cell-to-cell interaction. Maintenance of immune tolerance is achieved via modulation of effector CD4+ T helper 1, 2 or 17 (Th1, Th2, Th17) cells by Tregs. This review highlights the recent progress in the understanding of Tregs in different disorders of the respiratory system. Hindawi 2019-11-20 /pmc/articles/PMC6886321/ /pubmed/31827925 http://dx.doi.org/10.1155/2019/1907807 Text en Copyright © 2019 Rani Singh et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Singh, Rani
Alape, Daniel
de Lima, Andrés
Ascanio, Juan
Majid, Adnan
Gangadharan, Sidhu P.
Regulatory T Cells in Respiratory Health and Diseases
title Regulatory T Cells in Respiratory Health and Diseases
title_full Regulatory T Cells in Respiratory Health and Diseases
title_fullStr Regulatory T Cells in Respiratory Health and Diseases
title_full_unstemmed Regulatory T Cells in Respiratory Health and Diseases
title_short Regulatory T Cells in Respiratory Health and Diseases
title_sort regulatory t cells in respiratory health and diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886321/
https://www.ncbi.nlm.nih.gov/pubmed/31827925
http://dx.doi.org/10.1155/2019/1907807
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