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Effects of physical exercise on skeletal muscles of rats with cerebral ischemia

Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a tread...

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Autores principales: Melo, R.T.R., Damázio, L.C.M., Lima, M.C., Pereira, V.G., Okano, B.S., Monteiro, B.S., Natali, A.J., Carlo, R.J. Del, Maldonado, I.R.S.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886361/
https://www.ncbi.nlm.nih.gov/pubmed/31800730
http://dx.doi.org/10.1590/1414-431X20198576
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author Melo, R.T.R.
Damázio, L.C.M.
Lima, M.C.
Pereira, V.G.
Okano, B.S.
Monteiro, B.S.
Natali, A.J.
Carlo, R.J. Del
Maldonado, I.R.S.C.
author_facet Melo, R.T.R.
Damázio, L.C.M.
Lima, M.C.
Pereira, V.G.
Okano, B.S.
Monteiro, B.S.
Natali, A.J.
Carlo, R.J. Del
Maldonado, I.R.S.C.
author_sort Melo, R.T.R.
collection PubMed
description Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill training program prior to the induction of cerebral ischemia via occlusion of the middle cerebral artery (OMCA). A total of 24 Wistar rats were distributed into four groups: Sham-Sed: sedentary control animals (n=6), who underwent sham surgery (in which OMCA did not occur); Sham+Ex: control animals exercised before the sham surgery (n=6); I-Sed: sedentary animals with cerebral ischemia (n=6); and I+Ex: animals exercised before the induction of ischemia (n=6). The physical exercise consisted of treadmill training for five weeks, 30 min/day (5 days/week), at a speed of 14 m/min. The results showed that the type-I fibers presented greater fiber area in the exercised ischemic group (I+Ex: 2347.96±202.77 µm(2)) compared to the other groups (Sham-Sed: 1676.46±132.21 µm(2); Sham+Ex: 1647.63±191.09 µm(2); I+Ex: 1566.93±185.09 µm(2); P=0.0002). Our findings suggested that the angiogenesis process may have influenced muscle recovery and reduced muscle atrophy of type-I fibers in the animals that exercised before cerebral ischemia.
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spelling pubmed-68863612019-12-11 Effects of physical exercise on skeletal muscles of rats with cerebral ischemia Melo, R.T.R. Damázio, L.C.M. Lima, M.C. Pereira, V.G. Okano, B.S. Monteiro, B.S. Natali, A.J. Carlo, R.J. Del Maldonado, I.R.S.C. Braz J Med Biol Res Research Article Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill training program prior to the induction of cerebral ischemia via occlusion of the middle cerebral artery (OMCA). A total of 24 Wistar rats were distributed into four groups: Sham-Sed: sedentary control animals (n=6), who underwent sham surgery (in which OMCA did not occur); Sham+Ex: control animals exercised before the sham surgery (n=6); I-Sed: sedentary animals with cerebral ischemia (n=6); and I+Ex: animals exercised before the induction of ischemia (n=6). The physical exercise consisted of treadmill training for five weeks, 30 min/day (5 days/week), at a speed of 14 m/min. The results showed that the type-I fibers presented greater fiber area in the exercised ischemic group (I+Ex: 2347.96±202.77 µm(2)) compared to the other groups (Sham-Sed: 1676.46±132.21 µm(2); Sham+Ex: 1647.63±191.09 µm(2); I+Ex: 1566.93±185.09 µm(2); P=0.0002). Our findings suggested that the angiogenesis process may have influenced muscle recovery and reduced muscle atrophy of type-I fibers in the animals that exercised before cerebral ischemia. Associação Brasileira de Divulgação Científica 2019-11-28 /pmc/articles/PMC6886361/ /pubmed/31800730 http://dx.doi.org/10.1590/1414-431X20198576 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Melo, R.T.R.
Damázio, L.C.M.
Lima, M.C.
Pereira, V.G.
Okano, B.S.
Monteiro, B.S.
Natali, A.J.
Carlo, R.J. Del
Maldonado, I.R.S.C.
Effects of physical exercise on skeletal muscles of rats with cerebral ischemia
title Effects of physical exercise on skeletal muscles of rats with cerebral ischemia
title_full Effects of physical exercise on skeletal muscles of rats with cerebral ischemia
title_fullStr Effects of physical exercise on skeletal muscles of rats with cerebral ischemia
title_full_unstemmed Effects of physical exercise on skeletal muscles of rats with cerebral ischemia
title_short Effects of physical exercise on skeletal muscles of rats with cerebral ischemia
title_sort effects of physical exercise on skeletal muscles of rats with cerebral ischemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886361/
https://www.ncbi.nlm.nih.gov/pubmed/31800730
http://dx.doi.org/10.1590/1414-431X20198576
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