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Effects of physical exercise on skeletal muscles of rats with cerebral ischemia
Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a tread...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação Científica
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886361/ https://www.ncbi.nlm.nih.gov/pubmed/31800730 http://dx.doi.org/10.1590/1414-431X20198576 |
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author | Melo, R.T.R. Damázio, L.C.M. Lima, M.C. Pereira, V.G. Okano, B.S. Monteiro, B.S. Natali, A.J. Carlo, R.J. Del Maldonado, I.R.S.C. |
author_facet | Melo, R.T.R. Damázio, L.C.M. Lima, M.C. Pereira, V.G. Okano, B.S. Monteiro, B.S. Natali, A.J. Carlo, R.J. Del Maldonado, I.R.S.C. |
author_sort | Melo, R.T.R. |
collection | PubMed |
description | Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill training program prior to the induction of cerebral ischemia via occlusion of the middle cerebral artery (OMCA). A total of 24 Wistar rats were distributed into four groups: Sham-Sed: sedentary control animals (n=6), who underwent sham surgery (in which OMCA did not occur); Sham+Ex: control animals exercised before the sham surgery (n=6); I-Sed: sedentary animals with cerebral ischemia (n=6); and I+Ex: animals exercised before the induction of ischemia (n=6). The physical exercise consisted of treadmill training for five weeks, 30 min/day (5 days/week), at a speed of 14 m/min. The results showed that the type-I fibers presented greater fiber area in the exercised ischemic group (I+Ex: 2347.96±202.77 µm(2)) compared to the other groups (Sham-Sed: 1676.46±132.21 µm(2); Sham+Ex: 1647.63±191.09 µm(2); I+Ex: 1566.93±185.09 µm(2); P=0.0002). Our findings suggested that the angiogenesis process may have influenced muscle recovery and reduced muscle atrophy of type-I fibers in the animals that exercised before cerebral ischemia. |
format | Online Article Text |
id | pubmed-6886361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Associação Brasileira de Divulgação Científica |
record_format | MEDLINE/PubMed |
spelling | pubmed-68863612019-12-11 Effects of physical exercise on skeletal muscles of rats with cerebral ischemia Melo, R.T.R. Damázio, L.C.M. Lima, M.C. Pereira, V.G. Okano, B.S. Monteiro, B.S. Natali, A.J. Carlo, R.J. Del Maldonado, I.R.S.C. Braz J Med Biol Res Research Article Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill training program prior to the induction of cerebral ischemia via occlusion of the middle cerebral artery (OMCA). A total of 24 Wistar rats were distributed into four groups: Sham-Sed: sedentary control animals (n=6), who underwent sham surgery (in which OMCA did not occur); Sham+Ex: control animals exercised before the sham surgery (n=6); I-Sed: sedentary animals with cerebral ischemia (n=6); and I+Ex: animals exercised before the induction of ischemia (n=6). The physical exercise consisted of treadmill training for five weeks, 30 min/day (5 days/week), at a speed of 14 m/min. The results showed that the type-I fibers presented greater fiber area in the exercised ischemic group (I+Ex: 2347.96±202.77 µm(2)) compared to the other groups (Sham-Sed: 1676.46±132.21 µm(2); Sham+Ex: 1647.63±191.09 µm(2); I+Ex: 1566.93±185.09 µm(2); P=0.0002). Our findings suggested that the angiogenesis process may have influenced muscle recovery and reduced muscle atrophy of type-I fibers in the animals that exercised before cerebral ischemia. Associação Brasileira de Divulgação Científica 2019-11-28 /pmc/articles/PMC6886361/ /pubmed/31800730 http://dx.doi.org/10.1590/1414-431X20198576 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Melo, R.T.R. Damázio, L.C.M. Lima, M.C. Pereira, V.G. Okano, B.S. Monteiro, B.S. Natali, A.J. Carlo, R.J. Del Maldonado, I.R.S.C. Effects of physical exercise on skeletal muscles of rats with cerebral ischemia |
title | Effects of physical exercise on skeletal muscles of rats with cerebral ischemia |
title_full | Effects of physical exercise on skeletal muscles of rats with cerebral ischemia |
title_fullStr | Effects of physical exercise on skeletal muscles of rats with cerebral ischemia |
title_full_unstemmed | Effects of physical exercise on skeletal muscles of rats with cerebral ischemia |
title_short | Effects of physical exercise on skeletal muscles of rats with cerebral ischemia |
title_sort | effects of physical exercise on skeletal muscles of rats with cerebral ischemia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886361/ https://www.ncbi.nlm.nih.gov/pubmed/31800730 http://dx.doi.org/10.1590/1414-431X20198576 |
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