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How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma
Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. OBJECTIVE: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). METHODO...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculdade De Odontologia De Bauru - USP
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886392/ https://www.ncbi.nlm.nih.gov/pubmed/31800876 http://dx.doi.org/10.1590/1678-7757-2019-0198 |
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author | Rodrigues, Renata Miranda Bernardo, Vagner Gonçalves Da Silva, Sabrina Daniela Camisasca, Danielle Resende Faria, Paulo Antônio de Silvestre Dias, Fernando Luiz Pinto, Luís Felipe Ribeiro Albano, Rodolpho Mattos Bergmann, Anke Lourenço, Simone de Queiroz Chaves |
author_facet | Rodrigues, Renata Miranda Bernardo, Vagner Gonçalves Da Silva, Sabrina Daniela Camisasca, Danielle Resende Faria, Paulo Antônio de Silvestre Dias, Fernando Luiz Pinto, Luís Felipe Ribeiro Albano, Rodolpho Mattos Bergmann, Anke Lourenço, Simone de Queiroz Chaves |
author_sort | Rodrigues, Renata Miranda |
collection | PubMed |
description | Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. OBJECTIVE: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). METHODOLOGY: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). RESULTS: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. CONCLUSION: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC. |
format | Online Article Text |
id | pubmed-6886392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Faculdade De Odontologia De Bauru - USP |
record_format | MEDLINE/PubMed |
spelling | pubmed-68863922019-12-17 How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma Rodrigues, Renata Miranda Bernardo, Vagner Gonçalves Da Silva, Sabrina Daniela Camisasca, Danielle Resende Faria, Paulo Antônio de Silvestre Dias, Fernando Luiz Pinto, Luís Felipe Ribeiro Albano, Rodolpho Mattos Bergmann, Anke Lourenço, Simone de Queiroz Chaves J Appl Oral Sci Original Article Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. OBJECTIVE: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). METHODOLOGY: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). RESULTS: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. CONCLUSION: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC. Faculdade De Odontologia De Bauru - USP 2019-11-15 /pmc/articles/PMC6886392/ /pubmed/31800876 http://dx.doi.org/10.1590/1678-7757-2019-0198 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Rodrigues, Renata Miranda Bernardo, Vagner Gonçalves Da Silva, Sabrina Daniela Camisasca, Danielle Resende Faria, Paulo Antônio de Silvestre Dias, Fernando Luiz Pinto, Luís Felipe Ribeiro Albano, Rodolpho Mattos Bergmann, Anke Lourenço, Simone de Queiroz Chaves How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title | How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title_full | How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title_fullStr | How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title_full_unstemmed | How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title_short | How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title_sort | how pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886392/ https://www.ncbi.nlm.nih.gov/pubmed/31800876 http://dx.doi.org/10.1590/1678-7757-2019-0198 |
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