Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity

Chagas disease causes ~10,000 deaths each year, mainly in Latin America, where it is endemic. The currently available chemotherapeutic agents are ineffective in the chronic stage of the disease, and the lack of pharmaceutical innovation for Chagas disease highlights the urgent need for the developme...

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Detalles Bibliográficos
Autores principales: Ferreira, Rafael A. A., Pauli, Ivani, Sampaio, Thiago S., de Souza, Mariana L., Ferreira, Leonardo L. G., Magalhães, Luma G., Rezende, Celso de O., Ferreira, Rafaela S., Krogh, Renata, Dias, Luiz C., Andricopulo, Adriano D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886403/
https://www.ncbi.nlm.nih.gov/pubmed/31824926
http://dx.doi.org/10.3389/fchem.2019.00798

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