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Updates on the hematologic tumor microenvironment and its therapeutic targeting
In this review article, we present recent updates on the hematologic tumor microenvironment following the 3(rd) Scientific Workshop on the Haematological Tumour Microenvironment and its Therapeutic Targeting organized by the European School of Hematology, which took place at the Francis Crick Instit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ferrata Storti Foundation
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886423/ https://www.ncbi.nlm.nih.gov/pubmed/31515356 http://dx.doi.org/10.3324/haematol.2018.195396 |
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author | Forte, Dorian Krause, Daniela S. Andreeff, Michael Bonnet, Dominique Méndez-Ferrer, Simón |
author_facet | Forte, Dorian Krause, Daniela S. Andreeff, Michael Bonnet, Dominique Méndez-Ferrer, Simón |
author_sort | Forte, Dorian |
collection | PubMed |
description | In this review article, we present recent updates on the hematologic tumor microenvironment following the 3(rd) Scientific Workshop on the Haematological Tumour Microenvironment and its Therapeutic Targeting organized by the European School of Hematology, which took place at the Francis Crick Institute in London in February 2019. This review article is focused on recent scientific advances highlighted in the invited presentations at the meeting, which encompassed the normal and malignant niches supporting hematopoietic stem cells and their progeny. Given the precise focus, it does not discuss other relevant contributions in this field, which have been the scope of other recent reviews. The content covers basic research and possible clinical applications with the major therapeutic angle of utilizing basic knowledge to devise new strategies to target the tumor microenvironment in hematologic cancers. The review is structured in the following sections: (i) regulation of normal hematopoietic stem cell niches during development, adulthood and aging; (ii) metabolic adaptation and reprogramming in the tumor microenvironment; (iii) the key role of inflammation in reshaping the normal microenvironment and driving hematopoietic stem cell proliferation; (iv) current understanding of the tumor microenvironment in different malignancies, such as chronic lymphocytic leukemia, multiple myeloma, acute myeloid leukemia and myelodysplastic syndromes; and (v) the effects of therapies on the microenvironment and some opportunities to target the niche directly in order to improve current treatments. |
format | Online Article Text |
id | pubmed-6886423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ferrata Storti Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-68864232019-12-09 Updates on the hematologic tumor microenvironment and its therapeutic targeting Forte, Dorian Krause, Daniela S. Andreeff, Michael Bonnet, Dominique Méndez-Ferrer, Simón Haematologica Review Article In this review article, we present recent updates on the hematologic tumor microenvironment following the 3(rd) Scientific Workshop on the Haematological Tumour Microenvironment and its Therapeutic Targeting organized by the European School of Hematology, which took place at the Francis Crick Institute in London in February 2019. This review article is focused on recent scientific advances highlighted in the invited presentations at the meeting, which encompassed the normal and malignant niches supporting hematopoietic stem cells and their progeny. Given the precise focus, it does not discuss other relevant contributions in this field, which have been the scope of other recent reviews. The content covers basic research and possible clinical applications with the major therapeutic angle of utilizing basic knowledge to devise new strategies to target the tumor microenvironment in hematologic cancers. The review is structured in the following sections: (i) regulation of normal hematopoietic stem cell niches during development, adulthood and aging; (ii) metabolic adaptation and reprogramming in the tumor microenvironment; (iii) the key role of inflammation in reshaping the normal microenvironment and driving hematopoietic stem cell proliferation; (iv) current understanding of the tumor microenvironment in different malignancies, such as chronic lymphocytic leukemia, multiple myeloma, acute myeloid leukemia and myelodysplastic syndromes; and (v) the effects of therapies on the microenvironment and some opportunities to target the niche directly in order to improve current treatments. Ferrata Storti Foundation 2019-10 /pmc/articles/PMC6886423/ /pubmed/31515356 http://dx.doi.org/10.3324/haematol.2018.195396 Text en Copyright© 2019 Ferrata Storti Foundation Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher. |
spellingShingle | Review Article Forte, Dorian Krause, Daniela S. Andreeff, Michael Bonnet, Dominique Méndez-Ferrer, Simón Updates on the hematologic tumor microenvironment and its therapeutic targeting |
title | Updates on the hematologic tumor microenvironment and its therapeutic targeting |
title_full | Updates on the hematologic tumor microenvironment and its therapeutic targeting |
title_fullStr | Updates on the hematologic tumor microenvironment and its therapeutic targeting |
title_full_unstemmed | Updates on the hematologic tumor microenvironment and its therapeutic targeting |
title_short | Updates on the hematologic tumor microenvironment and its therapeutic targeting |
title_sort | updates on the hematologic tumor microenvironment and its therapeutic targeting |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886423/ https://www.ncbi.nlm.nih.gov/pubmed/31515356 http://dx.doi.org/10.3324/haematol.2018.195396 |
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