A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H(2)S-Activated Second Near-Infrared Emission for Bioimaging

Real-time and accurate detection of endogenous hydrogen sulfide is of great biomedical significance. Here, a FRET-based fluorescent probe for ratiometric detection of H(2)S was designed to comprise an AIE luminophore TPE as an energy donor and a monochlorinated BODIPY dye as an energy acceptor and H...

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Autores principales: Wang, Rongchen, Gao, Wei, Gao, Jie, Xu, Ge, Zhu, Tianli, Gu, Xianfeng, Zhao, Chunchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886478/
https://www.ncbi.nlm.nih.gov/pubmed/31824918
http://dx.doi.org/10.3389/fchem.2019.00778
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author Wang, Rongchen
Gao, Wei
Gao, Jie
Xu, Ge
Zhu, Tianli
Gu, Xianfeng
Zhao, Chunchang
author_facet Wang, Rongchen
Gao, Wei
Gao, Jie
Xu, Ge
Zhu, Tianli
Gu, Xianfeng
Zhao, Chunchang
author_sort Wang, Rongchen
collection PubMed
description Real-time and accurate detection of endogenous hydrogen sulfide is of great biomedical significance. Here, a FRET-based fluorescent probe for ratiometric detection of H(2)S was designed to comprise an AIE luminophore TPE as an energy donor and a monochlorinated BODIPY dye as an energy acceptor and H(2)S-responsive site. Such a designed probe showed H(2)S-dependent ratiometric and light-up NIR-II emission, enabling accurate imaging of H(2)S-rich cancer cells and identification of H(2)S-rich tumors with high resolution.
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spelling pubmed-68864782019-12-10 A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H(2)S-Activated Second Near-Infrared Emission for Bioimaging Wang, Rongchen Gao, Wei Gao, Jie Xu, Ge Zhu, Tianli Gu, Xianfeng Zhao, Chunchang Front Chem Chemistry Real-time and accurate detection of endogenous hydrogen sulfide is of great biomedical significance. Here, a FRET-based fluorescent probe for ratiometric detection of H(2)S was designed to comprise an AIE luminophore TPE as an energy donor and a monochlorinated BODIPY dye as an energy acceptor and H(2)S-responsive site. Such a designed probe showed H(2)S-dependent ratiometric and light-up NIR-II emission, enabling accurate imaging of H(2)S-rich cancer cells and identification of H(2)S-rich tumors with high resolution. Frontiers Media S.A. 2019-11-25 /pmc/articles/PMC6886478/ /pubmed/31824918 http://dx.doi.org/10.3389/fchem.2019.00778 Text en Copyright © 2019 Wang, Gao, Gao, Xu, Zhu, Gu and Zhao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wang, Rongchen
Gao, Wei
Gao, Jie
Xu, Ge
Zhu, Tianli
Gu, Xianfeng
Zhao, Chunchang
A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H(2)S-Activated Second Near-Infrared Emission for Bioimaging
title A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H(2)S-Activated Second Near-Infrared Emission for Bioimaging
title_full A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H(2)S-Activated Second Near-Infrared Emission for Bioimaging
title_fullStr A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H(2)S-Activated Second Near-Infrared Emission for Bioimaging
title_full_unstemmed A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H(2)S-Activated Second Near-Infrared Emission for Bioimaging
title_short A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H(2)S-Activated Second Near-Infrared Emission for Bioimaging
title_sort förster resonance energy transfer switchable fluorescent probe with h(2)s-activated second near-infrared emission for bioimaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886478/
https://www.ncbi.nlm.nih.gov/pubmed/31824918
http://dx.doi.org/10.3389/fchem.2019.00778
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