Cargando…

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S

Precision medicine has revolutionized the treatment of patients in EGFR driven non-small cell lung cancer (NSCLC). Targeted drugs show high response rates in genetically defined subsets of cancer patients and markedly increase their progression-free survival as compared to conventional chemotherapy....

Descripción completa

Detalles Bibliográficos
Autores principales:	Lategahn, Jonas, Keul, Marina, Klövekorn, Philip, Tumbrink, Hannah L., Niggenaber, Janina, Müller, Matthias P., Hodson, Luke, Flaßhoff, Maren, Hardick, Julia, Grabe, Tobias, Engel, Julian, Schultz-Fademrecht, Carsten, Baumann, Matthias, Ketzer, Julia, Mühlenberg, Thomas, Hiller, Wolf, Günther, Georgia, Unger, Anke, Müller, Heiko, Heimsoeth, Alena, Golz, Christopher, Blank-Landeshammer, Bernhard, Kollipara, Laxmikanth, Zahedi, René P., Strohmann, Carsten, Hengstler, Jan G., van Otterlo, Willem A. L., Bauer, Sebastian, Rauh, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886544/ https://www.ncbi.nlm.nih.gov/pubmed/31857889 http://dx.doi.org/10.1039/c9sc03445e

Ejemplares similares

Disentangling thermal stress responses in a reef-calcifier and its photosymbionts by shotgun proteomics
por: Stuhr, Marleen, et al.
Publicado: (2018)

Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK
por: Bührmann, Mike, et al.
Publicado: (2017)

rac-2-Phenyl-1-[(2,4,6-triisopropylbenzene)sulfonyl]aziridine
por: Golz, Christopher, et al.
Publicado: (2014)

Crystal structure of 1-[(2,4,6-triisopropylphenyl)sulfonyl]aziridine
por: Knauer, Lena, et al.
Publicado: (2015)

Crystal structure of di-μ-iodido-bis{[bis(piperidin-1-yl)methane-κ(2) N,N′]copper(I)}
por: Barth, Eva Rebecca, et al.
Publicado: (2015)

Crystal structure of 4-(trimethylgermyl)benzoic acid
por: Knauer, Lena, et al.
Publicado: (2015)

Crystal structure of di-μ-iodido-bis[bis(acetonitrile-κN)copper(I)]
por: Barth, Eva Rebecca, et al.
Publicado: (2015)

Crystal structures of diaquadi-μ-hydroxido-tris[trimethyltin(IV)] diformatotrimethylstannate(IV) and di-μ-hydroxido-tris[trimethyltin(IV)] chloride monohydrate
por: Otte, Felix, et al.
Publicado: (2016)

Crystal structure of rac-(3aR,4S,5aR,6S,9R,10aS,10bR)-3a,5a,9-trimethyltetradecahydro-6,9-epoxycyclohepta[e]inden-4-ol monohydrate
por: Schäfer, Andreas, et al.
Publicado: (2015)

Crystal structure of benzyl(methyl)phenyl[(piperidin-1-ium-1-yl)methyl]silane bromide
por: Barth, Eva Rebecca, et al.
Publicado: (2015)

DISMS2: A flexible algorithm for direct proteome- wide distance calculation of LC-MS/MS runs
por: Rieder, Vera, et al.
Publicado: (2017)

Crystal structure of dibenzyldimethylsilane
por: Knauer, Lena, et al.
Publicado: (2015)

Crystal structure of (E)-N′-{[(1R,3R)-3-isopropyl-1-methyl-2-oxocyclopentyl]methylidene}-4-methylbenzenesulfonohydrazide
por: Tymann, David, et al.
Publicado: (2015)

Crystal structure of N′-[(E)-(1S,3R)-(3-isopropyl-1-methyl-2-oxocyclopentyl)methylidene]-4-methylbenzenesulfonohydrazide
por: Tymann, David, et al.
Publicado: (2015)

Three-Component Access to Functionalized Spiropyrrolidine Heterocyclic Scaffolds and Their Cholinesterase Inhibitory Activity
por: Boudriga, Sarra, et al.
Publicado: (2020)

Highly diastereoselective construction of novel dispiropyrrolo[2,1-a]isoquinoline derivatives via multicomponent 1,3-dipolar cycloaddition of cyclic diketones-based tetrahydroisoquinolinium N-ylides
por: Boudriga, Sarra, et al.
Publicado: (2019)

Crystal structure of [2-(triethylammonio)ethyl][(2,4,6-triisopropylphenyl)sulfonyl]amide tetrahydrate
por: Golz, C., et al.
Publicado: (2015)

Edition Eulenburg No. 797, Horn Concerto, : Mi♭ majeur - E♭ major - Es dur KV 495 /

A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity
por: Lee, Yen-Chun, et al.
Publicado: (2017)

797. Tuberculosis Treatment: Combined Forms vs. Dissociated Forms
por: Trigui, Maroua, et al.
Publicado: (2018)

Overcoming EGFR(G724S)-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors
por: Fassunke, Jana, et al.
Publicado: (2018)

Cellular model system to dissect the isoform-selectivity of Akt inhibitors
por: Quambusch, Lena, et al.
Publicado: (2021)

Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase
por: Getlik, Matthäus, et al.
Publicado: (2012)

797 Viral co-infections in hospitalized patients with respiratory tract infections
por: Al-Nakib, Widad, et al.
Publicado: (2014)

Fractures After Denosumab Discontinuation: A Retrospective Study of 797 Cases
por: Burckhardt, Peter, et al.
Publicado: (2021)

Correction to Lancet Planet Health 2021; 5: e797–807
Publicado: (2021)

{2,2-Bis[(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]propane}bis(N,N-dimethylformamide)copper(II) bis[hexafluoridoantimonate(V)]
por: Zeh, Julia, et al.
Publicado: (2010)

Sorting Out the Risks and Benefits of the #797 Recommended Intrapartum Vancomycin Dosing Approach
por: Farkas, Andras, et al.
Publicado: (2022)

Structural insights into drug development strategy targeting EGFR T790M/C797S
por: Zhu, Su-Jie, et al.
Publicado: (2018)

Overcoming EGFR T790M and C797S resistance with mutant-selective allosteric inhibitors
por: Jia, Yong, et al.
Publicado: (2016)

Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin
por: Huang, Kuo-Yen, et al.
Publicado: (2021)

797. Infection Prevention and Control Training Needs and Preferences Among Frontline Health Professionals
por: Stream, Sarah, et al.
Publicado: (2021)

P797: METABOLIC PROFILING IN ERCC6L2 AND SHWACHMAN DIAMOND SYNDROME
por: Kaaja, I., et al.
Publicado: (2022)

Edição de Abril de 2022, vol. 118(42), págs. 797-857
Publicado: (2022)

Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt
por: Uhlenbrock, Niklas, et al.
Publicado: (2019)

tert-Butoxytriphenylsilane
por: Bauer, Jonathan O., et al.
Publicado: (2010)

Dibromido[(tert-butylamino)dimethyl(piperidin-1-ylmethyl)silane-κ(2) N,N′]zinc(II)
por: Colquhoun, Victoria P., et al.
Publicado: (2009)

Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach
por: van der Westhuizen, Leandi, et al.
Publicado: (2022)

Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data
por: Blank-Landeshammer, Bernhard, et al.
Publicado: (2019)

Enantioselective synthesis of tricyclic amino acid derivatives based on a rigid 4-azatricyclo[5.2.1.0(2,6)]decane skeleton
por: Breuning, Matthias, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_r2emf6c96ls32aavo69u1pata5