Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix

AIM: To determine if porcine urinary bladder matrix (UBM) treatment is associated with modulation of wound inflammation in diabetic patients. PATIENTS & METHODS: mRNA associated with M1 and M2 macrophages were measured in wounds of diabetic and nondiabetic patients pre- and post-treatment with UBM and an M1:M2 score was calculated. RESULTS: Wound tissue from diabetic subjects exhibited elevated M1:M2 scores compared with nondiabetic patients, suggesting a greater pro-inflammatory state prior to treatment. Post-treatment, there was significantly greater reduction in the magnitude of the individual M1:M2 scores in the diabetic patients resulting in similar levels in both groups of patients. CONCLUSIONS: UBM may assist in diabetic wound healing by restoring an inflammatory state similar to that of nondiabetic patients.