Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma

Core regulatory transcription factors (CR TFs) orchestrate the placement of super-enhancers (SEs) to activate transcription of cell-identity specifying gene networks, and are critical in promoting cancer. Here, we define the core regulatory circuitry of rhabdomyosarcoma (RMS) and identify critical C...

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Detalles Bibliográficos
Autores principales: Gryder, Berkley E., Pomella, Silvia, Sayers, Carly, Wu, Xiaoli S., Song, Young, Chiarella, Anna M., Bagchi, Sukriti, Chou, Hsien-Chao, Sinniah, Ranu S., Walton, Ashley, Wen, Xinyu, Rota, Rossella, Hathaway, Nathaniel A., Zhao, Keji, Chen, Jiji, Vakoc, Christopher R., Shern, Jack F., Stanton, Benjamin Z., Khan, Javed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886578/
https://www.ncbi.nlm.nih.gov/pubmed/31784732
http://dx.doi.org/10.1038/s41588-019-0534-4

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