Activity-by-Contact model of enhancer-promoter regulation from thousands of CRISPR perturbations

Enhancer elements in the human genome control how genes are expressed in specific cell types and harbor thousands of genetic variants that influence risk for common diseases(1–4). Yet, we still do not know how enhancers regulate specific genes, and we lack general rules to predict enhancer-gene conn...

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Detalles Bibliográficos
Autores principales: Fulco, Charles P., Nasser, Joseph, Jones, Thouis R., Munson, Glen, Bergman, Drew T., Subramanian, Vidya, Grossman, Sharon R., Anyoha, Rockwell, Doughty, Benjamin R., Patwardhan, Tejal A., Nguyen, Tung H., Kane, Michael, Perez, Elizabeth M., Durand, Neva C., Lareau, Caleb A., Stamenova, Elena K., Aiden, Erez Lieberman, Lander, Eric S., Engreitz, Jesse M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886585/
https://www.ncbi.nlm.nih.gov/pubmed/31784727
http://dx.doi.org/10.1038/s41588-019-0538-0

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