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Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells

An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain largely unknown. Here, we show that aneuploidy disrupts the...

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Detalles Bibliográficos
Autores principales:	Hwang, Sunyoung, Williams, Jessica F., Kneissig, Maja, Lioudyno, Maria, Rivera, Isabel, Helguera, Pablo, Busciglio, Jorge, Storchova, Zuzana, King, Megan C., Torres, Eduardo M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886690/ https://www.ncbi.nlm.nih.gov/pubmed/31747614 http://dx.doi.org/10.1016/j.celrep.2019.10.059

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