Lack of detectable neoantigen depletion signals in the untreated cancer genome

Somatic mutations can result in the formation of neoantigens, immunogenic peptides that are presented on the tumor cell surface via HLA molecules. These mutations are expected to be under negative selection pressure, but the extent of the resulting neoantigen depletion remains unclear. Based on HLA...

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Detalles Bibliográficos
Autores principales: Van den Eynden, Jimmy, Jiménez-Sánchez, Alejandro, Miller, Martin L., Larsson, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887557/
https://www.ncbi.nlm.nih.gov/pubmed/31768072
http://dx.doi.org/10.1038/s41588-019-0532-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887557/
https://www.ncbi.nlm.nih.gov/pubmed/31768072
http://dx.doi.org/10.1038/s41588-019-0532-6

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