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PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC
PTPRS is the most commonly mutated receptor tyrosine phosphatase in colorectal cancer (CRC). PTPRS has been shown to directly affect ERK and regulate its activation and nuclear localization. Here we identify that PTPRS may play a significant role in developing adaptive resistance to MEK/ERK inhibito...
Autores principales: | Davis, Thomas B., Yang, Mingli, Wang, Heiman, Lee, Changgong, Yeatman, Timothy J., Pledger, W. Jack |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887575/ https://www.ncbi.nlm.nih.gov/pubmed/31827720 http://dx.doi.org/10.18632/oncotarget.27335 |
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