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Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma
Multiple myeloma (MM) progresses mainly in the bone marrow where the involvement of a specific microenvironment plays a critical role in maintaining plasma cell growth, spread, and survival. In active disease, the switch from a pre-vascular/non-active phase to a vascular phase is coupled with the im...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887577/ https://www.ncbi.nlm.nih.gov/pubmed/31827721 http://dx.doi.org/10.18632/oncotarget.27285 |
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author | Pacini, Simone Montali, Marina Mazziotta, Francesco Schifone, Claudia P. Macchia, Lucia Carnicelli, Vittoria Panvini, Francesca M. Barachini, Serena Notarfranchi, Laura Previti, Giovanni Battista Buda, Gabriele Petrini, Mario |
author_facet | Pacini, Simone Montali, Marina Mazziotta, Francesco Schifone, Claudia P. Macchia, Lucia Carnicelli, Vittoria Panvini, Francesca M. Barachini, Serena Notarfranchi, Laura Previti, Giovanni Battista Buda, Gabriele Petrini, Mario |
author_sort | Pacini, Simone |
collection | PubMed |
description | Multiple myeloma (MM) progresses mainly in the bone marrow where the involvement of a specific microenvironment plays a critical role in maintaining plasma cell growth, spread, and survival. In active disease, the switch from a pre-vascular/non-active phase to a vascular phase is coupled with the impairment of bone turnover. Previously, we have isolated Mesangiogenic Progenitor Cells (MPCs), a bone marrow population that showed mesengenic and angiogenic potential, both in vitro and in vivo. MPC differentiation into musculoskeletal tissue and their ability of sprouting angiogenesis are mutually exclusive, suggesting a role in the imbalancing of the microenvironment in multiple myeloma. MPCs from 32 bone marrow samples of multiple myeloma and 23 non-hematological patients were compared in terms of frequency, phenotype, mesengenic/angiogenic potential, and gene expression profile. Defective osteogenesis was recorded for MM-derived MPCs that showed longer angiogenic sprouting distances respect to non-hematological MPCs, retaining this capability after mesengenic induction. This altered MPCs differentiation potential was not detected in asymptomatic myelomatous disease. These in vitro experiments are suggestive of a forced angiogenic fate in MPCs isolated from MM patients, which also showed increased sprouting activity. Taking together our results suggest a possible role of these cells in the “angiogenic switch” in the MM micro-environment. |
format | Online Article Text |
id | pubmed-6887577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-68875772019-12-11 Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma Pacini, Simone Montali, Marina Mazziotta, Francesco Schifone, Claudia P. Macchia, Lucia Carnicelli, Vittoria Panvini, Francesca M. Barachini, Serena Notarfranchi, Laura Previti, Giovanni Battista Buda, Gabriele Petrini, Mario Oncotarget Research Paper Multiple myeloma (MM) progresses mainly in the bone marrow where the involvement of a specific microenvironment plays a critical role in maintaining plasma cell growth, spread, and survival. In active disease, the switch from a pre-vascular/non-active phase to a vascular phase is coupled with the impairment of bone turnover. Previously, we have isolated Mesangiogenic Progenitor Cells (MPCs), a bone marrow population that showed mesengenic and angiogenic potential, both in vitro and in vivo. MPC differentiation into musculoskeletal tissue and their ability of sprouting angiogenesis are mutually exclusive, suggesting a role in the imbalancing of the microenvironment in multiple myeloma. MPCs from 32 bone marrow samples of multiple myeloma and 23 non-hematological patients were compared in terms of frequency, phenotype, mesengenic/angiogenic potential, and gene expression profile. Defective osteogenesis was recorded for MM-derived MPCs that showed longer angiogenic sprouting distances respect to non-hematological MPCs, retaining this capability after mesengenic induction. This altered MPCs differentiation potential was not detected in asymptomatic myelomatous disease. These in vitro experiments are suggestive of a forced angiogenic fate in MPCs isolated from MM patients, which also showed increased sprouting activity. Taking together our results suggest a possible role of these cells in the “angiogenic switch” in the MM micro-environment. Impact Journals LLC 2019-11-26 /pmc/articles/PMC6887577/ /pubmed/31827721 http://dx.doi.org/10.18632/oncotarget.27285 Text en Copyright: © 2019 Pacini et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Pacini, Simone Montali, Marina Mazziotta, Francesco Schifone, Claudia P. Macchia, Lucia Carnicelli, Vittoria Panvini, Francesca M. Barachini, Serena Notarfranchi, Laura Previti, Giovanni Battista Buda, Gabriele Petrini, Mario Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma |
title | Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma |
title_full | Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma |
title_fullStr | Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma |
title_full_unstemmed | Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma |
title_short | Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma |
title_sort | mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887577/ https://www.ncbi.nlm.nih.gov/pubmed/31827721 http://dx.doi.org/10.18632/oncotarget.27285 |
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