Improved Tumor Purity Metrics in Next-generation Sequencing for Clinical Practice: The Integrated Interpretation of Neoplastic Cellularity and Sequencing Results (IINCaSe) Approach

Neoplastic cellularity contributes to the analytic sensitivity of most present technologies for mutation detection, such that they underperform when stroma and inflammatory cells dilute a cancer specimen’s variant fraction. Thus, tumor purity assessment by light microscopy is used to determine sampl...

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Detalles Bibliográficos
Autores principales: Patel, Nirali M., Jo, Heejoon, Eberhard, David A., Yin, Xiaoying, Hayward, Michele C., Stein, Matthew K., Hayes, David Neil, Grilley-Olson, Juneko E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887630/
https://www.ncbi.nlm.nih.gov/pubmed/30102605
http://dx.doi.org/10.1097/PAI.0000000000000684

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