Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease

Aging and aging‐related CNS diseases are associated with inflammatory status. As an efficient amplifier of immune responses, inflammasome is activated and played detrimental role in aging and aging‐related CNS diseases. Macrophage and microglia display robust inflammasome activation in infectious an...

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Detalles Bibliográficos
Autores principales: Hu, Meng‐yan, Lin, Yin‐yao, Zhang, Bing‐jun, Lu, Dan‐li, Lu, Zheng‐qi, Cai, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887669/
https://www.ncbi.nlm.nih.gov/pubmed/31729181
http://dx.doi.org/10.1111/cns.13262
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author Hu, Meng‐yan
Lin, Yin‐yao
Zhang, Bing‐jun
Lu, Dan‐li
Lu, Zheng‐qi
Cai, Wei
author_facet Hu, Meng‐yan
Lin, Yin‐yao
Zhang, Bing‐jun
Lu, Dan‐li
Lu, Zheng‐qi
Cai, Wei
author_sort Hu, Meng‐yan
collection PubMed
description Aging and aging‐related CNS diseases are associated with inflammatory status. As an efficient amplifier of immune responses, inflammasome is activated and played detrimental role in aging and aging‐related CNS diseases. Macrophage and microglia display robust inflammasome activation in infectious and sterile inflammation. This review discussed the impact of inflammasome activation in microglia/macrophage on senescence “inflammaging” and aging‐related CNS diseases. The preventive or therapeutic effects of targeting inflammasome on retarding aging process or tackling aging‐related diseases are also discussed.
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spelling pubmed-68876692019-12-12 Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease Hu, Meng‐yan Lin, Yin‐yao Zhang, Bing‐jun Lu, Dan‐li Lu, Zheng‐qi Cai, Wei CNS Neurosci Ther Review Articles Aging and aging‐related CNS diseases are associated with inflammatory status. As an efficient amplifier of immune responses, inflammasome is activated and played detrimental role in aging and aging‐related CNS diseases. Macrophage and microglia display robust inflammasome activation in infectious and sterile inflammation. This review discussed the impact of inflammasome activation in microglia/macrophage on senescence “inflammaging” and aging‐related CNS diseases. The preventive or therapeutic effects of targeting inflammasome on retarding aging process or tackling aging‐related diseases are also discussed. John Wiley and Sons Inc. 2019-11-14 /pmc/articles/PMC6887669/ /pubmed/31729181 http://dx.doi.org/10.1111/cns.13262 Text en © 2019 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Hu, Meng‐yan
Lin, Yin‐yao
Zhang, Bing‐jun
Lu, Dan‐li
Lu, Zheng‐qi
Cai, Wei
Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease
title Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease
title_full Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease
title_fullStr Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease
title_full_unstemmed Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease
title_short Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease
title_sort update of inflammasome activation in microglia/macrophage in aging and aging‐related disease
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887669/
https://www.ncbi.nlm.nih.gov/pubmed/31729181
http://dx.doi.org/10.1111/cns.13262
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