rAAV Engineering for Capsid-Protein Enzyme Insertions and Mosaicism Reveals Resilience to Mutational, Structural and Thermal Perturbations

Recombinant adeno-associated viruses (rAAV) provide outstanding options for customization and superior capabilities for gene therapy. To access their full potential, facile genetic manipulation is pivotal, including capsid loop modifications. Therefore, we assessed capsid tolerance to modifications...

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Detalles Bibliográficos
Autores principales: Feiner, Rebecca C., Teschner, Julian, Teschner, Kathrin E., Radukic, Marco T., Baumann, Tobias, Hagen, Sven, Hannappel, Yvonne, Biere, Niklas, Anselmetti, Dario, Arndt, Katja M., Müller, Kristian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887778/
https://www.ncbi.nlm.nih.gov/pubmed/31739438
http://dx.doi.org/10.3390/ijms20225702

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