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Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population

Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples...

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Autores principales: Otsuka, Ikuo, Akiyama, Masato, Shirakawa, Osamu, Okazaki, Satoshi, Momozawa, Yukihide, Kamatani, Yoichiro, Izumi, Takeshi, Numata, Shusuke, Takahashi, Motonori, Boku, Shuken, Sora, Ichiro, Yamamoto, Ken, Ueno, Yasuhiro, Toda, Tatsushi, Kubo, Michiaki, Hishimoto, Akitoyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887868/
https://www.ncbi.nlm.nih.gov/pubmed/31476763
http://dx.doi.org/10.1038/s41386-019-0506-5
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author Otsuka, Ikuo
Akiyama, Masato
Shirakawa, Osamu
Okazaki, Satoshi
Momozawa, Yukihide
Kamatani, Yoichiro
Izumi, Takeshi
Numata, Shusuke
Takahashi, Motonori
Boku, Shuken
Sora, Ichiro
Yamamoto, Ken
Ueno, Yasuhiro
Toda, Tatsushi
Kubo, Michiaki
Hishimoto, Akitoyo
author_facet Otsuka, Ikuo
Akiyama, Masato
Shirakawa, Osamu
Okazaki, Satoshi
Momozawa, Yukihide
Kamatani, Yoichiro
Izumi, Takeshi
Numata, Shusuke
Takahashi, Motonori
Boku, Shuken
Sora, Ichiro
Yamamoto, Ken
Ueno, Yasuhiro
Toda, Tatsushi
Kubo, Michiaki
Hishimoto, Akitoyo
author_sort Otsuka, Ikuo
collection PubMed
description Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35–48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (P(best) = 2.7 × 10(−13)) by polygenic risk score analysis. This study is the first genome-wide association study for suicidal behavior in an East Asian population, and our results provided the evidence of polygenic architecture underlying completed suicide.
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spelling pubmed-68878682019-12-06 Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population Otsuka, Ikuo Akiyama, Masato Shirakawa, Osamu Okazaki, Satoshi Momozawa, Yukihide Kamatani, Yoichiro Izumi, Takeshi Numata, Shusuke Takahashi, Motonori Boku, Shuken Sora, Ichiro Yamamoto, Ken Ueno, Yasuhiro Toda, Tatsushi Kubo, Michiaki Hishimoto, Akitoyo Neuropsychopharmacology Article Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35–48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (P(best) = 2.7 × 10(−13)) by polygenic risk score analysis. This study is the first genome-wide association study for suicidal behavior in an East Asian population, and our results provided the evidence of polygenic architecture underlying completed suicide. Springer International Publishing 2019-09-02 2019-11 /pmc/articles/PMC6887868/ /pubmed/31476763 http://dx.doi.org/10.1038/s41386-019-0506-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Otsuka, Ikuo
Akiyama, Masato
Shirakawa, Osamu
Okazaki, Satoshi
Momozawa, Yukihide
Kamatani, Yoichiro
Izumi, Takeshi
Numata, Shusuke
Takahashi, Motonori
Boku, Shuken
Sora, Ichiro
Yamamoto, Ken
Ueno, Yasuhiro
Toda, Tatsushi
Kubo, Michiaki
Hishimoto, Akitoyo
Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population
title Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population
title_full Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population
title_fullStr Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population
title_full_unstemmed Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population
title_short Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population
title_sort genome-wide association studies identify polygenic effects for completed suicide in the japanese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887868/
https://www.ncbi.nlm.nih.gov/pubmed/31476763
http://dx.doi.org/10.1038/s41386-019-0506-5
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