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Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors

Protein kinases orchestrate diverse cellular functions; however, their dysregulation is linked to metabolic dysfunctions, associated with many diseases, including cancer. Mitogen-Activated Protein (MAP) kinase is a notoriously oncogenic signaling pathway in human malignancies, where the extracellula...

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Detalles Bibliográficos
Autores principales:	Halawa, Ahmed H., Eskandrani, Areej A., Elgammal, Walid E., Hassan, Saber M., Hassan, Ahmed H., Ebrahim, Hassan Y., Mehany, Ahmed B. M., El-Agrody, Ahmed M., Okasha, Rawda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888105/ https://www.ncbi.nlm.nih.gov/pubmed/31717402 http://dx.doi.org/10.3390/ijms20225592

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