Cargando…
Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer
Bioactive glasses (BGs) are routinely being used as potent materials for hard and soft tissue engineering applications; however, improving their biological activities through surface functionalization and modification has been underestimated so far. The surface characteristics of BGs are key factors...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888252/ https://www.ncbi.nlm.nih.gov/pubmed/31717516 http://dx.doi.org/10.3390/ma12223696 |
_version_ | 1783475186244255744 |
---|---|
author | Kargozar, Saeid Kermani, Farzad Mollazadeh Beidokhti, Sahar Hamzehlou, Sepideh Verné, Enrica Ferraris, Sara Baino, Francesco |
author_facet | Kargozar, Saeid Kermani, Farzad Mollazadeh Beidokhti, Sahar Hamzehlou, Sepideh Verné, Enrica Ferraris, Sara Baino, Francesco |
author_sort | Kargozar, Saeid |
collection | PubMed |
description | Bioactive glasses (BGs) are routinely being used as potent materials for hard and soft tissue engineering applications; however, improving their biological activities through surface functionalization and modification has been underestimated so far. The surface characteristics of BGs are key factors in determining the success of any implanted BG-based material in vivo since they regulate the affinity and binding of different biological macromolecules and thereby the interactions between cells and the implant. Therefore, a number of strategies using chemical agents (e.g., glutaraldehyde, silanes) and physical methods (e.g., laser treatment) have been evaluated and applied to design properly, tailor, and improve the surface properties of BGs. All these approaches aim at enhancing the biological activities of BGs, including the induction of cell proliferation and subsequent osteogenesis, as well as the inhibition of bacterial growth and adhesion, thereby reducing infection. In this study, we present an overview of the currently used approaches of surface functionalization and modifications of BGs, along with discussing the biological outputs induced by these changes. |
format | Online Article Text |
id | pubmed-6888252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68882522019-12-09 Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer Kargozar, Saeid Kermani, Farzad Mollazadeh Beidokhti, Sahar Hamzehlou, Sepideh Verné, Enrica Ferraris, Sara Baino, Francesco Materials (Basel) Review Bioactive glasses (BGs) are routinely being used as potent materials for hard and soft tissue engineering applications; however, improving their biological activities through surface functionalization and modification has been underestimated so far. The surface characteristics of BGs are key factors in determining the success of any implanted BG-based material in vivo since they regulate the affinity and binding of different biological macromolecules and thereby the interactions between cells and the implant. Therefore, a number of strategies using chemical agents (e.g., glutaraldehyde, silanes) and physical methods (e.g., laser treatment) have been evaluated and applied to design properly, tailor, and improve the surface properties of BGs. All these approaches aim at enhancing the biological activities of BGs, including the induction of cell proliferation and subsequent osteogenesis, as well as the inhibition of bacterial growth and adhesion, thereby reducing infection. In this study, we present an overview of the currently used approaches of surface functionalization and modifications of BGs, along with discussing the biological outputs induced by these changes. MDPI 2019-11-09 /pmc/articles/PMC6888252/ /pubmed/31717516 http://dx.doi.org/10.3390/ma12223696 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kargozar, Saeid Kermani, Farzad Mollazadeh Beidokhti, Sahar Hamzehlou, Sepideh Verné, Enrica Ferraris, Sara Baino, Francesco Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer |
title | Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer |
title_full | Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer |
title_fullStr | Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer |
title_full_unstemmed | Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer |
title_short | Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer |
title_sort | functionalization and surface modifications of bioactive glasses (bgs): tailoring of the biological response working on the outermost surface layer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888252/ https://www.ncbi.nlm.nih.gov/pubmed/31717516 http://dx.doi.org/10.3390/ma12223696 |
work_keys_str_mv | AT kargozarsaeid functionalizationandsurfacemodificationsofbioactiveglassesbgstailoringofthebiologicalresponseworkingontheoutermostsurfacelayer AT kermanifarzad functionalizationandsurfacemodificationsofbioactiveglassesbgstailoringofthebiologicalresponseworkingontheoutermostsurfacelayer AT mollazadehbeidokhtisahar functionalizationandsurfacemodificationsofbioactiveglassesbgstailoringofthebiologicalresponseworkingontheoutermostsurfacelayer AT hamzehlousepideh functionalizationandsurfacemodificationsofbioactiveglassesbgstailoringofthebiologicalresponseworkingontheoutermostsurfacelayer AT verneenrica functionalizationandsurfacemodificationsofbioactiveglassesbgstailoringofthebiologicalresponseworkingontheoutermostsurfacelayer AT ferrarissara functionalizationandsurfacemodificationsofbioactiveglassesbgstailoringofthebiologicalresponseworkingontheoutermostsurfacelayer AT bainofrancesco functionalizationandsurfacemodificationsofbioactiveglassesbgstailoringofthebiologicalresponseworkingontheoutermostsurfacelayer |