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Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury

Prolonged exposure to nicotine accelerates onset and progression of renal diseases in habitual cigarette smokers. Exposure to nicotine, either via active or passive smoking is strongly shown to enhance renal oxidative stress and augment kidney failure in various animal models. In this study, we inve...

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Autores principales: Ramalingam, Anand, Santhanathas, Thulasiprevinnah, Shaukat Ali, Shafreena, Zainalabidin, Satirah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888267/
https://www.ncbi.nlm.nih.gov/pubmed/31726798
http://dx.doi.org/10.3390/ijerph16224445
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author Ramalingam, Anand
Santhanathas, Thulasiprevinnah
Shaukat Ali, Shafreena
Zainalabidin, Satirah
author_facet Ramalingam, Anand
Santhanathas, Thulasiprevinnah
Shaukat Ali, Shafreena
Zainalabidin, Satirah
author_sort Ramalingam, Anand
collection PubMed
description Prolonged exposure to nicotine accelerates onset and progression of renal diseases in habitual cigarette smokers. Exposure to nicotine, either via active or passive smoking is strongly shown to enhance renal oxidative stress and augment kidney failure in various animal models. In this study, we investigated the effects of resveratrol supplementation on nicotine-induced kidney injury and oxidative stress in a rat model. Male Sprague-Dawley rats were given nicotine (0.6 mg/kg, i.p.) alone or in combination with either resveratrol (8 mg/kg, i.p.), or angiotensin II type I receptor blocker, irbesartan (10 mg/kg, p.o.) for 28 days. Upon completion of treatment, kidneys were investigated for changes in structure, kidney injury markers and oxidative stress. Administration of nicotine alone for 28 days resulted in significant renal impairment as shown by marked increase in plasma creatinine, blood urea nitrogen (BUN) and oxidative stress. Co-administration with resveratrol however successfully attenuated these changes, with a concomitant increase in renal antioxidants such as glutathione similar to the conventionally used angiotensin II receptor blocker, irbesartan. These data altogether suggest that targeting renal oxidative stress with resveratrol could alleviate nicotine-induced renal injury. Antioxidants may be clinically important for management of renal function in habitual smokers.
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spelling pubmed-68882672019-12-09 Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury Ramalingam, Anand Santhanathas, Thulasiprevinnah Shaukat Ali, Shafreena Zainalabidin, Satirah Int J Environ Res Public Health Article Prolonged exposure to nicotine accelerates onset and progression of renal diseases in habitual cigarette smokers. Exposure to nicotine, either via active or passive smoking is strongly shown to enhance renal oxidative stress and augment kidney failure in various animal models. In this study, we investigated the effects of resveratrol supplementation on nicotine-induced kidney injury and oxidative stress in a rat model. Male Sprague-Dawley rats were given nicotine (0.6 mg/kg, i.p.) alone or in combination with either resveratrol (8 mg/kg, i.p.), or angiotensin II type I receptor blocker, irbesartan (10 mg/kg, p.o.) for 28 days. Upon completion of treatment, kidneys were investigated for changes in structure, kidney injury markers and oxidative stress. Administration of nicotine alone for 28 days resulted in significant renal impairment as shown by marked increase in plasma creatinine, blood urea nitrogen (BUN) and oxidative stress. Co-administration with resveratrol however successfully attenuated these changes, with a concomitant increase in renal antioxidants such as glutathione similar to the conventionally used angiotensin II receptor blocker, irbesartan. These data altogether suggest that targeting renal oxidative stress with resveratrol could alleviate nicotine-induced renal injury. Antioxidants may be clinically important for management of renal function in habitual smokers. MDPI 2019-11-12 2019-11 /pmc/articles/PMC6888267/ /pubmed/31726798 http://dx.doi.org/10.3390/ijerph16224445 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ramalingam, Anand
Santhanathas, Thulasiprevinnah
Shaukat Ali, Shafreena
Zainalabidin, Satirah
Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury
title Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury
title_full Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury
title_fullStr Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury
title_full_unstemmed Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury
title_short Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury
title_sort resveratrol supplementation protects against nicotine-induced kidney injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888267/
https://www.ncbi.nlm.nih.gov/pubmed/31726798
http://dx.doi.org/10.3390/ijerph16224445
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