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CRISPR/Cas9-Mediated Knock-Out of Kras(G12D) Mutated Pancreatic Cancer Cell Lines

In 90% of pancreatic ductal adenocarcinoma cases, genetic alteration of the proto-oncogene Kras has occurred, leading to uncontrolled proliferation of cancerous cells. Targeting Kras has proven to be difficult and the battle against pancreatic cancer is ongoing. A promising approach to combat cancer...

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Detalles Bibliográficos
Autores principales:	Lentsch, Eva, Li, Lifei, Pfeffer, Susanne, Ekici, Arif B., Taher, Leila, Pilarsky, Christian, Grützmann, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888344/ https://www.ncbi.nlm.nih.gov/pubmed/31739488 http://dx.doi.org/10.3390/ijms20225706

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