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Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that recognizes post-transcriptionally abnormal transcripts and mediates their degradation. The master regulator of NMD is UPF1, an enzyme with intrinsic ATPase and helicase activities. The cancer genomic sequencing data has identifie...

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Detalles Bibliográficos
Autores principales:	Kalathiya, Umesh, Padariya, Monikaben, Pawlicka, Kamila, Verma, Chandra S., Houston, Douglas, Hupp, Ted R., Alfaro, Javier Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888360/ https://www.ncbi.nlm.nih.gov/pubmed/31718065 http://dx.doi.org/10.3390/ijms20225644

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